ArticleJournal of medical virology2026
Synergistic Interaction Between HPV-16 E7 Oncoprotein and Severe Vitamin A Deficiency in Regulating Adaptive Immunity in a Preclinical Cervical Cancer Model.
Article in Journal of medical virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Persistent infection with High-Risk Human Papillomavirus (HR-HPV), particularly HPV-16, is the main driver of cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). However, HR-HPV infection alone is insufficient for malignant progression and nutritional cofactors such as Vitamin A deficiency, may influence cervical neoplasia progression through immune dysregulation. This study aimed to explore the interaction between HPV-16 E7 oncoprotein expression and severe Vitamin A Deficiency (VAD), as well as the effects of a Vitamin A-Normal Diet Reintegration (NDR) on adaptive immune regulation in cervical neoplasia using the K14E7 preclinical murine model. We found that VAD worsening cervical epithelial changes and impairs the cytotoxic ability of CD8
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