Evidence map›Paper›PMID 42265841›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Five-year change in brain metabolism across the spectrum of cognitive impairment in older adults: a quantitative MRI study.

Jiani Wu, Kumiko Oishi, Anja Soldan, Corinne Pettigrew, Zixuan Lin, Yuxin Zhu, Dengrong Jiang, Xin Li, Yifan Gou, Abhay Moghekar and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jiani WuDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Kumiko OishiDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Anja SoldanDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Corinne PettigrewDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Zixuan LinDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Yuxin ZhuDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Dengrong JiangDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Xin LiDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Yifan GouDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Abhay MoghekarDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Peiying LiuDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Arnold BakkerDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Kenichi OishiDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Marilyn AlbertDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Hanzhang LuDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0003-3871-1564

Funding

Project 2 MeasurementU19AG033655 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT, Arnold Bakker · 2014 to 2026
$51.5M
TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
An integrated vascular MR imaging suite in brain diseasesR01NS106702 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2018 to 2022
$2.7M
Non-contrast MR imaging of blood-brain-barrier permeability in Alzheimer's diseaseR01AG064792 · NIA · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2020 to 2023
$2.6M
Physiological imaging markers in vascular contributions to cognitive impairment and dementia (VCID)R01AG085299 · NIA · JOHNS HOPKINS UNIVERSITY · PI Hanzhang Lu · 2024 to 2026
$2.3M
MR fingerprinting (MRF) perfusion imaging in cerebral vascular diseaseR01NS106711 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2018 to 2022
$2.2M
State of the Art 3T Research ScannerS10OD021648 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2016 to 2016
$2.0M
Blood-brain barrier dysfunction in Alzheimer's disease: from humans to animal modelsR01AG071515 · NIA · JOHNS HOPKINS UNIVERSITY · PI Hanzhang Lu · 2024 to 2026
$1.6M
MR imaging of venous transit time in vascular cognitive impairment and dementiaR01AG091312 · NIA · JOHNS HOPKINS UNIVERSITY · PI Hanzhang Lu · 2026 to 2026
$465k
Early imaging markers for elderly individuals with high risk to develop Alzheimer's diseaseR21AG055153 · NIA · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2016 to 2017
$449k
NIH HHS P41 EB031771NIH HHS R01 AG064792NIH HHS R01 AG071515NIH HHS R01 AG085299NIH HHS R01 AG091312NIH HHS R01 NS106702NIH HHS R01 NS106711NIH HHS R21 AG055153NIH HHS S10 OD021648NIH HHS U19 AG033655
6 · The paper itself

Abstract

introductionIt is desirable to measure brain metabolism without needing ionizing radiation and elucidate its time trajectory. This study employed a positron emission tomography -validated, non-invasive magnetic resonance imaging (MRI) technique to characterize longitudinal changes in cerebral metabolic rate of oxygen (CMRO

methodsParticipants received serial MRI-based CMRO

resultsAt the initial visit, participants with MCI/dementia had lower CMRO DISCUSSION: Aside from the well-known metabolic slowdown in the later phases of AD, the brain exhibits tau-dependent hypermetabolism during the preclinical stage.

Indexed as

BrainCognitive DysfunctionMagnetic Resonance ImagingAgedAged, 80 and overFemaleHumansLongitudinal StudiesMaleOxygenPositron-Emission Tomographytau ProteinsOxygentau ProteinsagingAlzheimer's diseasebrain metabolismcerebral metabolic rate of oxygen (CMRO2)magnetic resonance imaging (MRI)tau

Identifiers

PMID42265841
PMCPMC13249794

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.