Trial reportBMC surgery2026
Early postoperative pain and quality of life with different modalities of mesh fixation in laparoscopic trans-abdominal pre-peritoneal repair of inguinal hernia: a randomized controlled trial.
Trial report in BMC surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07401082 (Postoperative Pain and Quality of Life With Different Modalities of Mesh Fixation in Laparoscopic Trans-Abdominal Pre-Peritoneal Repair of Inguinal Hernia. A Randomized Controlled Trial), which is not on this map. Not yet cited in PubMed.
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The trial behind it
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Postoperative Pain and Quality of Life With Different Modalities of Mesh Fixation in Laparoscopic Trans-Abdominal Pre-Peritoneal Repair of Inguinal Hernia. A Randomized Controlled Trial
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Authors and funding
4 authors.
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Abstract
backgroundCompared with open inguinal hernia repair, laparoscopic approaches, including Transabdominal Preperitoneal (TAPP) and Totally Extraperitoneal (TEP), improve recovery and reduce pain. However, optimal mesh fixation remains unclear due to limited high-quality comparative evidence. We aimed to evaluate early postoperative pain and quality of life with different mesh fixation modalities (glue, tacks, and sutures) in laparoscopic TAPP inguinal hernia repair.
methodsA single-center, prospective, randomized controlled trial was conducted on 75 eligible adult patients with primary inguinal hernia scheduled for elective TAPP repair. Patients were randomized in a 1:1:1 ratio to glue (n = 25), suture (n = 25), or tack (n = 25) fixation. Primary outcomes were postoperative pain intensity (visual analogue scale, VAS) and hernia-specific quality of life (Carolinas Comfort Scale, CCS) assessed at postoperative day 1 1, 3, and 6 months. Secondary outcomes included operative time, length of hospital stay, time to return to work, complications, recurrence, and procedural cost.
resultsCompared with the glue and suture fixation groups, the tack fixation group had substantially higher pain levels on the first day after the operation and at one month (P < 0.001). Over the 3rd and 6th months, VAS scores were low and comparable across all groups, with no significant differences. The glue group had significantly lower mesh sensation and total CCS scores at all time points compared to the suture and tack groups (P < 0.001).
conclusionsIn the early postoperative period following laparoscopic TAPP inguinal hernia repair, mesh fixation with surgical glue results in superior pain control, better quality of life, and faster return to work compared to sutures and tacks, without increasing early complication rates.
trial registrationClinicalTrials.gov Identifier: NCT07401082 (Registered February 6, 2026; retrospectively registered after completion of enrollment).
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