Evidence map›Paper›PMID 42265628›Full record

ArticleBMC ophthalmology2026

Polarimetric entropy mapping of retinal pigment epithelium in full-thickness macular hole by polarization-sensitive OCT.

Ryo Terao, Kazuki Yashiro, Takuya Kuriyama, Kosei Babaguchi, Gen Mihara, Kosuke Nakajima, Shuichiro Aoki, Takahiro Arai, Kohdai Kitamoto, Keiko Azuma and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ryo TeraoDepartment of Ophthalmology, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan. terao-oph@g.ecc.u-tokyo.ac.jp.
Kazuki YashiroDepartment of Ophthalmology, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Takuya KuriyamaDepartment of Ophthalmology, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Kosei BabaguchiDepartment of Ophthalmology, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Gen MiharaDepartment of Ophthalmology, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Kosuke NakajimaDepartment of Ophthalmology, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Shuichiro AokiDepartment of Ophthalmology, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Takahiro AraiDepartment of Ophthalmology, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Kohdai KitamotoDepartment of Ophthalmology, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Keiko AzumaDepartment of Ophthalmology, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Takashi UetaDepartment of Ophthalmology, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study is aimed to evaluate retinal pigment epithelium (RPE) entropy in eyes with full-thickness macular hole (FTMH) using polarization-sensitive optical coherence tomography (PS-OCT).

methodsPatients diagnosed with treatment-naïve FTMH who underwent pars plana vitrectomy with internal limiting membrane peeling were included. Ophthalmologic examinations, including visual acuity (BCVA), swept-source OCT (SS-OCT), and PS-OCT, were performed. Polarimetric entropy (PE) of RPE was assessed using PS-OCT and compared with affected and fellow eyes and before and after surgery.

resultsFourteen eyes of 14 patients were included (64.5 ± 5.84 years). All eyes achieved complete FTMH closure following the surgery. PE value within the central foveal area (< 200 μm from the foveal center) was significantly lower than that in fellow eyes (p = 0.013), whereas PE in the area surrounding FTMH was significantly higher (p = 0.0402). The interocular difference in foveal PE (affected eye minus fellow eye) was significantly and negatively correlated with baseline BCVA (p = 0.0445). Postoperatively, PE in the surrounding area significantly decreased, whereas foveal PE did not change. Eyes without EZ recovery exhibited significantly greater baseline foveal PE reduction than those with EZ recovery (p = 0.0053).

conclusionsThese findings suggest two spatially distinct RPE responses in FTMH: decreased entropy in the foveal area and increased entropy in the surrounding region. Foveal RPE-PE quantified by PS-OCT is associated with EZ recovery and may reflect postoperative structural outcomes.

Indexed as

Retinal PerforationsRetinal Pigment EpitheliumTomography, Optical CoherenceAgedEntropyFemaleFovea CentralisHumansMaleMiddle AgedRetrospective StudiesVisual AcuityVitrectomyMacular holePolarization sensitive optical coherence tomographyRetinal pigment epitheliumVitrectomy

Identifiers

PMID42265628
PMCPMC13471266

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.