Evidence map›Paper›PMID 42265580›Full record

ArticleBMC genomics2026

Differential expression of Musashi 2 in single and double corpus luteum of hybrid Mongolian sheep.

Hao Qinqin, Li Penghui, Zhu Hefeng, Cao Guifang, Liu Haodong, He Yang, Zhang Zelin, Fan Jiaxin, Yin Junzhe, Li Yongqiang and 2 more

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Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Hao Qinqin *College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, 010018, China.
Li Penghui *College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, 010018, China.
Zhu Hefeng *College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, 010018, China.
Cao GuifangCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, 010018, China.
Liu HaodongCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, 010018, China.
He YangCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, 010018, China.
Zhang ZelinCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, 010018, China.
Fan JiaxinCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, 010018, China.
Yin JunzheCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, 010018, China.
Li YongqiangInner Mongolia Huimu Animal Husbandry Co., Ltd, Xing'an League, Inner Mongolia, 137401, China.
Xu DanInner Mongolia Sangao Animal Husbandry Co., Ltd, Xing'an League, Inner Mongolia, 137401, China.
Du ChenguangCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, 010018, China. du@imau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to investigate the differential expression of Musashi 2 (MSI2) in the single and double corpus lutea of Mongolian sheep (Xing'an black sheep) and its role in multiparity.

resultsResults showed two synonymous SNPs identified in the exons of MSI2. MSI2 was co-localized with GDF9/BMP15 in follicles and corpus lutea. MSI2 expression was significantly higher in single corpus luteum, whereas GDF9/BMP15 expression was higher in double corpus luteum. Pearson's correlation analysis revealed significant negative correlations between mRNA and protein expression of MSI2 and GDF9, BMP15. The double corpus luteum group exhibited higher levels of P4, LH, E

conclusionsThis study preliminarily elucidates the expression pattern of MSI2 in the corpus luteum of Mongolian sheep. It provides a theoretical basis for exploring the molecular regulatory mechanism of prolificacy in Mongolian sheep, and also offers a potential target for improving the reproductive performance of Mongolian sheep via molecular breeding techniques.

Indexed as

Corpus LuteumRNA-Binding ProteinsAnimalsBone Morphogenetic Protein 15FemaleGene Expression ProfilingGene Expression RegulationGrowth Differentiation Factor 9Polymorphism, Single NucleotideSheepBone Morphogenetic Protein 15Growth Differentiation Factor 9RNA-Binding ProteinsMongolian sheepMSI2Prolificacy traitSingle/double corpus luteumSingle nucleotide polymorphism

Identifiers

PMID42265580
PMCPMC13595504

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