ArticleOdontology2026
Comparison of cytotoxicity and physicochemical properties of Cal Bio LC MTA, ProRoot MTA and NeoPutty MTA: an in vitro study.
Article in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium silicate-based cements are widely used for vital pulp therapy (VPT); however, newer formulations such as premixed putty and light‑curable resin‑modified MTAs may differ in handling, bioactivity, and biocompatibility. This study compared the cytotoxicity and key physicochemical properties of Cal‑Bio LC MTA, ProRoot MTA and NeoPutty MTA. Three calcium silicate-based cements were evaluated in vitro (n = 5 per test). Setting time, flow, and radiopacity were assessed according to ISO 6876:2012; radiopacity was calculated as mm Al using an aluminum step wedge. Solubility (mass loss, %) was assessed at 1, 7 and 30 days (ISO 6876), while water sorption, solubility (µg/mm³), and porosity were assessed at 30 days (ISO 4049:2019). pH changes of set specimens were measured after 24 h, 7 d and 30 d. Compressive strength (4 × 6 mm cylinders) and Vickers microhardness were measured. FT-IR (ATR, 4000-400 cm⁻¹) was used to characterize functional groups. Cytotoxicity was assessed on human dermal fibroblasts using an extract‑based MTT assay and IC₅₀ values were calculated. Data were statistically analysed using Kruskal-Wallis H test (α = 0.05). Cal‑Bio LC MTA exhibited the shortest setting time, the highest flowability, compressive strength, and microhardness values (p < .05). While ProRoot MTA and NeoPutty MTA displayed higher radiopacity values (p < .05) radiopacity of all materials exceeded 3 mm Al. All materials met the ISO 6876 solubility limit (< 3%). ProRoot MTA exhibited the highest alkalinity over time and the highest cytocompatibility (IC₅₀ >147.224), followed by NeoPutty (IC₅₀ 91.59) and Cal‑Bio LC (IC₅₀ 78.79). Material formulation and setting mechanism strongly influenced biological and physicochemical properties. Cal‑Bio LC MTA provided superior early handling and mechanical properties, whereas ProRoot MTA showed higher alkalinity and better cytocompatibility.
Indexed as
Identifiers
42265500What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.