Evidence map›Paper›PMID 42265467›Full record

ArticleNature aging2026

Single-nucleus interrogation of primate small intestinal aging reveals NCoR1 decline as a conserved feature that is reversed by metformin.

Jingyi Li, Xiaoyong Lu, Tianhong Tong, Xin Zhou, Baohu Zhang, Xiaoyan Sun, Bing Zhao, Gang Xu, Jinjiang Yang, Yanling Fan and 15 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Jingyi Li *State Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-3126-7889
Xiaoyong Lu *University of Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0009-0007-6084-7376
Tianhong Tong *State Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Xin Zhou *Department of General Surgery, Cancer Center, Beijing Key Laboratory for Interdisciplinary Research in Gastrointestinal Oncology (BLGO), Peking University Third Hospital, Beijing, China.
Baohu Zhang *State Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Xiaoyan Sun *University of Chinese Academy of Sciences, Beijing, China.
Bing Zhao *The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.
Gang Xu *Liver Transplant Center, Organ Transplant Center, West China Hospital of Sichuan University, Chengdu, China.
Jinjiang YangState Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Yanling FanChina National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
Jianli HuUniversity of Chinese Academy of Sciences, Beijing, China.
Haoteng YanAdvanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, China.
Zhejun JiState Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Mingheng LiState Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Shanshan CheUniversity of Chinese Academy of Sciences, Beijing, China.
Yuanhan YangState Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Yingjie DingUniversity of Chinese Academy of Sciences, Beijing, China.
Qiaoran WangUniversity of Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0003-1886-4854
Shuhui SunBeijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Shuai MaState Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-8858-4383
Si WangAging Biomarker Consortium (ABC), Beijing, China.ORCID http://orcid.org/0000-0003-2431-0612
Juan Carlos Izpisua BelmonteAltos Labs, San Diego Institute of Science, California, CA, USA.ORCID http://orcid.org/0000-0003-0557-8875
Jing QuState Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. qujing@ioz.ac.cn.ORCID http://orcid.org/0000-0002-3988-5067
Weiqi ZhangUniversity of Chinese Academy of Sciences, Beijing, China. zhangwq@big.ac.cn.ORCID http://orcid.org/0000-0002-8885-5104
Guang-Hui LiuState Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn.ORCID http://orcid.org/0000-0001-9289-8177

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

How the small intestine ages at the cellular and molecular level has been unclear. Here we profile single nuclei from young and aged primate small intestine and find that aging brings barrier dysfunction, chronic inflammation and a shift in stem cell differentiation away from absorptive cells toward secretory cells. Through integrative multimodal analysis, we identify the transcriptional corepressor NCoR1 as a key player whose decline is conserved in the aging human gut. In human intestinal epithelial cells and organoids, knocking down NCOR1 recapitulates aging phenotypes including senescence, disrupted junctions and lineage imbalance, whereas overexpressing NCoR1 alleviates them. Metformin-a geroprotective drug-restores NCoR1 levels and delays intestinal aging in nonhuman primates. Our work points to NCoR1 as a central regulator of small intestinal aging and suggests a pharmacologically actionable strategy to counter age-related intestinal decline.

Indexed as

AgingCell NucleusIntestine, SmallMetforminNuclear Receptor Co-Repressor 1AnimalsHumansIntestinal Barrier FunctionIntestinal MucosaMetforminNCOR1 protein, humanNuclear Receptor Co-Repressor 1

Identifiers

PMID42265467

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.