Evidence map›Paper›PMID 42265437›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Cannabidiol corrects sleep deficits and reduces spontaneous seizures in Angelman syndrome model mice.

Tyler Shannon, Mariam Najeeb, Yoon-Jae Yi, Yuyan Shen, Bin Gu

Abstract read
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In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tyler ShannonDepartment of Neuroscience, The Ohio State University, Columbus, OH, USA.
Mariam NajeebDepartment of Neuroscience, The Ohio State University, Columbus, OH, USA.
Yoon-Jae YiDepartment of Neuroscience, The Ohio State University, Columbus, OH, USA.
Yuyan ShenDepartment of Neuroscience, The Ohio State University, Columbus, OH, USA.
Bin GuDepartment of Neuroscience, The Ohio State University, Columbus, OH, USA. bin.gu@osumc.edu.ORCID http://orcid.org/0000-0002-6846-5563

Funding

Jazz Pharmaceuticals (Jazz Pharmaceuticals plc) IST-22-1-12204
6 · The paper itself

Abstract

The off-label use of cannabidiol (CBD) has outpaced investigation. We assessed the effects of CBD in Angelman syndrome model mice lacking the Ube3a gene and found that chronic injection of CBD increased rapid-eye movement sleep during the dark cycle, restored "Siesta", improved sleep homeostasis, and reduced spontaneous seizures following flurothyl kindling.

Indexed as

Angelman SyndromeCannabidiolSeizuresSleep Wake DisordersAnimalsDisease Models, AnimalKindling, NeurologicMaleMiceMice, Inbred C57BLMice, KnockoutUbiquitin-Protein LigasesCannabidiolUbe3a protein, mouseUbiquitin-Protein Ligases

Identifiers

PMID42265437
PMCPMC13389062

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.