Evidence map›Paper›PMID 42265376›Full record

ArticleCommunications biology2026

Functional and morphological alterations of light detection circuits in postmortem retina from donors with different stages of Alzheimer's-like pathology.

Nicolae Sanda, Dan Milea, Eniko Kovari, Yixin Tong, Arianna Cella, Talayeh Brügger, Jens Hannibal, Kristof Levente Egervari, Johannes Alexander Lobrinus, Emmanuel Carrera and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nicolae SandaFribourg Cantonal Hospital, Neurology Department, Fribourg, Switzerland.
Dan MileaRothschild Foundation Hospital, Neuro-ophthalmology Department, Paris, France.
Eniko KovariFaculty of medicine, University of Geneva, Geneva, Switzerland.
Yixin TongInselspital, Department of Ophthalmology, Bern, Switzerland.
Arianna CellaInselspital, Department of Ophthalmology, Bern, Switzerland.
Talayeh BrüggerUniversity of Bern, Institute of Physiology, Bern, Switzerland.
Jens HannibalDepartment of Clinical Biochemistry, Bispebjerg Hospital, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-9416-0125
Kristof Levente EgervariGeneva University Hospital, Neuropathology Unit, Geneva, Switzerland.
Johannes Alexander LobrinusGeneva University Hospital, Neuropathology Unit, Geneva, Switzerland.
Emmanuel CarreraDepartment of Clinical Neurosciences, Geneva University, Geneva, Switzerland.
Gabriele ThumannDepartment of Clinical Neurosciences, Geneva University, Geneva, Switzerland.
Sonja KleinlogelUniversity of Bern, Institute of Physiology, Bern, Switzerland.
Antoine AdamantidisUniversity of Bern, DBMR, Bern, Switzerland.
Ludovic S MureInselspital, Department of Ophthalmology, Bern, Switzerland. ludovic.mure@unibe.ch.ORCID http://orcid.org/0000-0002-2485-1032

Funding

Velux Stiftung (Velux Foundation) 1429
6 · The paper itself

Abstract

Disruption of sleep and circadian rhythms is one of the earliest symptoms of Alzheimer's disease (AD). Circadian entrainment and modulation of alertness are non-visual responses to light driven by intrinsically photosensitive retinal ganglion cells (ipRGCs). To explore structural and functional changes of ipRGCs and ipRGC circuits in AD, we analyzed the retinas and brains of 13 elderly patients ranging from normal cognition to AD and performed ex vivo extracellular electrophysiological recordings on freshly harvested retinas. While no impairment of rods and cones was observed, there was a severe loss of ipRGCs in AD donors. Importantly, the remaining ipRGCs exhibited morphological alterations, hyperexcitability, and were not able to sustain high levels of activation. These changes may be ipRGC subtype-specific and vary across donors with pathological severity. Altered ipRGC circuits and function could contribute to the disruption of sleep and circadian rhythms reported in AD patients. Measuring ipRGC-dependent responses to light could be a promising way to predict or monitor pathological changes in the brain.

Indexed as

Alzheimer DiseaseLightRetinaRetinal Ganglion CellsAgedAged, 80 and overCircadian RhythmFemaleHumansMale

Identifiers

PMID42265376
PMCPMC13594353

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.