ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Effect of a nurse-led dyadic symptom management intervention on postoperative esophageal cancer patients and their family caregivers: A quasi-experimental trial with a qualitative process evaluation.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate the effects of a dyadic symptom management intervention on health outcomes of postoperative esophageal cancer patients and their caregivers.
methodsA quasi-experimental study was conducted involving 84 esophageal cancer patients and their caregivers at a cancer center in Southern China. Participants in the control group received standard perioperative care, whereas those in the intervention group underwent four structured educational sessions and received symptom management consultations during the first postoperative month. Primary outcomes included patients' symptom burden and difference in symptom assessment between patients and their caregivers. Secondary outcomes included dyadic communication, depression, anxiety, and quality of life. Generalized estimating equation models were applied for data analysis. Semi-structured interviews were conducted for the process evaluation.
resultsStatistically significant differences were observed between groups in dyadic symptom severity assessments, patient symptom severity and interference, the 31-day unplanned readmission rate, as well as dyadic anxiety, depression, and the mental component summary. No significant differences were found in dyadic symptom interference assessments, family communication, or the physical component summary of the dyads. Qualitative process evaluation identified three main themes: (1) security and gratitude, (2) adapting together, healing together, and (3) sustainable support and resources.
conclusionOur findings suggest that the nurse-led dyadic symptom management intervention may improve symptom management and psychological outcomes (e.g., anxiety and depression) among postoperative esophageal cancer patients and their family caregivers. REGISTRATION: This study was retrospectively registered with the Chinese Clinical Trial Registry on 10 June 2025 (ChiCTR2500104063).
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