Evidence map›Paper›PMID 42265346›Full record

ArticleNature structural & molecular biology2026

Temperature and intrinsic Ca

Jinhong Hu, Sofia Ievleva, Sung Jin Park, Junuk Lee, Jie Cheng, Garrett O'Dea, Jiangnan Sheng, Juan Du, Wei Lü

Abstract read
In one paragraph

Article in Nature structural & molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jinhong HuDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Sofia IevlevaDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0002-6436-647X
Sung Jin ParkDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0002-4834-8001
Junuk LeeDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Jie ChengDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0002-4694-0183
Garrett O'DeaDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0009-0004-8708-2199
Jiangnan ShengDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0009-0003-4239-1695
Juan DuDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA. juan.du@northwestern.edu.ORCID http://orcid.org/0000-0003-1467-1203
Wei LüDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA. wei.lu@northwestern.edu.ORCID http://orcid.org/0000-0002-3009-1025

Funding

Structural and Functional Studies of the TRPM4 and TRPM5 ChannelsR01HL153219 · NHLBI · VAN ANDEL RESEARCH INSTITUTE · PI Wei Lu · 2020 to 2026
$3.9M
Structural Basis of Nociceptor Channel TRPM3 gating and pharmacologyR01NS129804 · NINDS · VAN ANDEL RESEARCH INSTITUTE · PI Juan Du · 2023 to 2026
$2.8M
Structural and functional studies of the TRPM2 channelR01NS111031 · NINDS · VAN ANDEL RESEARCH INSTITUTE · PI DU, JUAN · 2019 to 2023
$2.7M
Structural and functional studies of CALHM channelsR01NS112363 · NINDS · VAN ANDEL RESEARCH INSTITUTE · PI LU, WEI · 2020 to 2024
$2.3M
Elucidating structures and molecular mechanisms of Pannexin channelsR35GM138321 · NIGMS · VAN ANDEL RESEARCH INSTITUTE · PI LU, WEI · 2020 to 2024
$2.3M
NHLBI NIH HHS R01 HL153219NIGMS NIH HHS R35 GM138321NINDS NIH HHS R01 NS111031NINDS NIH HHS R01 NS112363NINDS NIH HHS R01 NS129804
6 · The paper itself

Abstract

Proteins operate in dynamic environments where ions, lipids and temperature collectively define their properties, yet most studies rely on simplified conditions that overlook these intrinsic variables. Here we show two such factors-temperature and Ca

Indexed as

CalciumTRPM Cation ChannelsAnimalsBinding SitesHEK293 CellsHumansLigandsModels, MolecularProtein BindingTemperatureCalciumLigandsTRPM4 protein, humanTRPM Cation Channels

Identifiers

PMID42265346
PMCPMC13275316

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.