Evidence map›Paper›PMID 42265324›Full record

ArticleScientific reports2026

HMGA2 identified via m6A-senescence multi-omics in laryngeal squamous cell carcinoma.

Meng Jin, Lingmei Qu, Zhaonan Xu, Shuang Teng, Shuo Liu, Qiuying Li, Fengshuo Zhang, Qing Hao, Peng Wang, Rui Zhao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Meng Jin *Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, 150086, China.
Lingmei Qu *Department of Otorhinolaryngology, Head and Neck Surgery, The Fifth Affiliated Hospital, Harbin Medical University, Harbin, 150040, China.
Zhaonan XuDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, 150086, China.
Shuang TengDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, 150086, China.
Shuo LiuDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, 150086, China.
Qiuying LiDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, 150086, China.
Fengshuo ZhangDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, 150086, China.
Qing HaoDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, 150086, China.
Peng WangDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, 150086, China.
Rui ZhaoDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, 150086, China. cczzww110@163.com.
Bingrui YanDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, 150086, China. ybryrs1995@126.com.
Yanan SunDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, 150086, China. h04015@hrbmu.edu.cn.

Funding

National Natural Science Foundation of China No. 82473035National Natural Science Foundation of China No. 82573272Natural Science Foundation of Heilongjiang Province LH2022H009Youth Project of Heilongjiang Natural Science Foundation YQ2022H008
6 · The paper itself

Abstract

N6-methyladenosine (m6A) modification and cellular senescence have been individually implicated in tumor biology, but the landscape of m6A-related senescence genes in laryngeal squamous cell carcinoma (LSCC) remains underexplored. In this study, we conducted an integrated multi-omics analysis combining bulk and single-cell transcriptomics, somatic mutation and copy number variation data, and proteomics to explore the clinical and molecular impacts of m6A-related senescence. We identified 93 putative m6A-related senescence genes with prognostic value, defining molecular subtypes with distinct immune features, survival outcomes, and pathway activities. Further stratification using differentially expressed genes revealed additional heterogeneity, and a derived m6A-related senescence score (m6ASenScore) showed robust associations with prognosis and mutation burden. Single-cell analysis uncovered malignant epithelial subpopulations with subtype-specific metabolic and inflammatory profiles. Among five core candidate genes, HMGA2 was found to be significantly upregulated at the protein level. Functional experiments in LSCC cell lines showed that reducing HMGA2 levels inhibited cell growth, invasion, and migration. This study provides a comprehensive characterization of m6A-related senescence signatures and highlights HMGA2 as a potential therapeutic target in LSCC.

Indexed as

AdenosineCarcinoma, Squamous CellCellular SenescenceHMGA2 ProteinLaryngeal NeoplasmsCell Line, TumorCell MovementCell ProliferationDNA Copy Number VariationsGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMultiomicsMutationPrognosisProteomicsAdenosineHMGA2 ProteinHMGA2 protein, humanN-methyladenosineHMGA2Laryngeal squamous cell carcinomam6ASenescenceSingle-cell RNA sequencing

Identifiers

PMID42265324
PMCPMC13494028

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.