ArticleNature genetics2026
Spatially resolved single-cell analyses of human meningioma identify novel cell states influencing tumor microenvironment and progression.
Article in Nature genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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18 authors.
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Abstract
Recent advances in our understanding of the molecular landscape of meningioma have generated new insights into the biology and heterogeneity of this disease, with demonstrated clinical value. However, there remains a need to understand tumor-intrinsic heterogeneity at single-cell resolution to inform potential therapeutic avenues. In this study, we examined the breadth of cell types and states in meningioma using a large cohort profiled with single-nuclear RNA sequencing and high-resolution spatial transcriptomics, as well as bulk DNA methylation and RNA sequencing (n = 712), bulk proteomics (n = 88) and plasma methylation (n = 59). We demonstrated that myeloid cell states differ across molecular groups of meningiomas and evolve meaningfully from dura to tumor. Myeloid cell states were also associated with unique myeloid-neoplastic interactions and neoplastic gene programs, suggesting a role in shaping the microenvironment. Finally, multiple non-neoplastic cell states refined outcome prediction beyond molecular group, suggesting a role in meningioma progression.
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