Evidence map›Paper›PMID 42265309›Full record

ArticleNature genetics2026

Inflammatory cytokines induce new cancer dependencies.

Collins K Cheruiyot, Sarah Y Kim, Juan Dubrot, Sarah K Lane-Reticker, Alex Miranda, Ashwin V Kammula, Jonathan J Perera, Peter P Du, Cun Lan Chuong, Rachel A Fetterman and 20 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Collins K CheruiyotBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Sarah Y KimBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Juan DubrotBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-8093-2208
Sarah K Lane-RetickerBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Alex MirandaBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Ashwin V KammulaBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5284-721X
Jonathan J PereraBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-3224-6075
Peter P DuBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-2652-0541
Cun Lan ChuongBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Rachel A FettermanBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Nelson H KnudsenBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-0384-1097
Aiping JiangBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-8389-2950
Juliette S M T SuermondtBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Lomax F PassBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Cong FuBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Meng-Ju WuBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6847-7065
Lei ShiBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1149-0474
Seth AndersonBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-2419-0585
Audrey J MuscatoBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-2009-6313
Omar I AvilaBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-3853-9939
Ian C KohnleBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Emily A KesslerBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-2608-6020
Hans W PopeBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Sarah G NoelBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0009-0006-9223-207X
Kira E OlanderBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-3356-7631
Jooho ChungBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-3625-0143
Kayla J ColvinBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Nabeel BardeesyBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Kathleen B YatesBroad Institute of MIT and Harvard, Cambridge, MA, USA. yates@broadinstitute.org.ORCID http://orcid.org/0000-0002-7383-5573
Robert T MangusoBroad Institute of MIT and Harvard, Cambridge, MA, USA. rmanguso@mgh.harvard.edu.ORCID http://orcid.org/0000-0003-1336-413X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor cells respond and adapt to environmental stresses that facilitate growth in hostile environments, including cytokine-mediated inflammation elicited by antitumor immunity and enhanced by immune checkpoint blockade (ICB). However, cytokine responses also induce transcriptional and cell-state changes that may predispose tumor cells to new vulnerabilities, which remain poorly explored. Here we performed in vitro genome-scale CRISPR loss-of-function screens in eight cancer models exposed to interferon-γ (IFNγ), interferon-β or tumor necrosis factor to map inflammation-induced genetic vulnerabilities. We identified members of the glycosylphosphatidylinositol (GPI) transamidase complex and the lipid phosphatase FITM2 as interferon-specific cancer dependencies. Tumor-specific deletion of GPI transamidase subunits or FITM2 markedly enhanced response to ICB in vivo. By integrating functional genomics, metabolomics and pharmacologic perturbation of downstream stress pathways, we found that loss of FITM2 predisposed cancer cells to IFNγ-driven endoplasmic reticulum and oxidative stress, culminating in paraptosis-like cell death. Collectively, these findings identify tumor-intrinsic dependencies governing responses to inflammatory cytokines.

Indexed as

CytokinesInflammationNeoplasmsAnimalsCell Line, TumorHumansInterferon-gammaMiceOxidative StressTumor Necrosis Factor-alphaCytokinesInterferon-gammaTumor Necrosis Factor-alpha

Identifiers

PMID42265309

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.