The EF-hand domain of MINDY3 is a ubiquitin and RAD23 UBL-binding domain.

Lee A Armstrong, Matthew R McFarland, Rachel O'Dea, Roscislaw Krutyholowa, Magdalena Gorka, Thomas Carroll, Sebastian Glatt, Yogesh Kulathu

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Article in EMBO reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Lee A ArmstrongMRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, Scotland, UK.

Matthew R McFarland *MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, Scotland, UK.ORCID 0009-0004-4308-7545

Rachel O'Dea *MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, Scotland, UK.

Roscislaw KrutyholowaMalopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland.ORCID 0000-0002-8200-5627

Magdalena GorkaMRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, Scotland, UK.

Thomas CarrollDundee Imaging Facility, School of Life Sciences, University of Dundee, Dundee, Scotland, UK.ORCID 0000-0002-0183-7924

Sebastian GlattMalopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland.ORCID 0000-0003-2815-7133

Yogesh KulathuMRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, Scotland, UK. ykulathu@dundee.ac.uk.ORCID 0000-0002-3274-1642

Funding

6 · The paper itself

Abstract

The MINDY family of deubiquitinases (DUBs) are exemplified by their preference for cleaving K48-linked polyubiquitin. MINDY3 is architecturally distinct from other MINDY DUBs as its catalytic domain spans the entire length of the protein except for an atypical EF-hand insertion. We uncover this EF-hand (MINDY3

Indexed as

DNA-Binding ProteinsDNA Repair EnzymesSaccharomyces cerevisiae ProteinsUbiquitinAmino Acid SequenceBinding SitesDNA DamageHumansModels, MolecularPolyubiquitinProtein BindingProtein DomainsSaccharomyces cerevisiaeDNA-Binding ProteinsDNA Repair EnzymesPolyubiquitinRAD23A protein, humanRAD23B protein, humanRAD23 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsUbiquitin

Identifiers

PMID42265305

DOI10.1038/s44319-026-00825-1

PMCPMC13354579

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.