ArticleScientific reports2026
Therapeutic potential of photoimmunotherapy in solid tumors expressing CD98 heavy chain.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Near-infrared photoimmunotherapy (NIR-PIT) is an emerging targeted cancer therapy that uses an antibody-photoabsorber conjugate. In this study, we evaluated the therapeutic potential of NIR-PIT targeting CD98 heavy chain (CD98hc), a transmembrane glycoprotein that is highly expressed in various solid tumors and is associated with poor prognosis. We prepared a conjugate of the clinically tested anti-CD98hc antibody IGN523 and photoabsorber IRDye700DX (IGN523-IR700). The therapeutic efficacy was assessed in vitro using four CD98hc-expressing cancer cell lines and in an in vivo tumor xenograft mouse model. In vitro, IGN523-IR700 binds to cancer cells and induces rapid and light dose-dependent cell death upon near-infrared light exposure. In the in vivo model, intravenous administration of IGN523-IR700 followed by tumor-directed light irradiation resulted in significant tumor growth inhibition compared with that in the control groups. These results demonstrate that CD98hc is a viable and effective target for NIR-PIT. Given its widespread expression, targeting CD98hc may significantly broaden the applicability of NIR-PIT to diverse cancer types.
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