Evidence map›Paper›PMID 42265291›Full record

ArticleSurgical endoscopy2026

Robotic-assisted cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC): a minimally invasive approach for peritoneal carcinomatosis in patients with low burden disease.

Andrea Bertolucci, Niccolò Ramacciotti, Lorenzo Piccini, Erion Rreka, Piero Vincenzo Lippolis

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Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Andrea BertolucciGeneral and Peritoneal Surgery Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Niccolò RamacciottiGeneral and Peritoneal Surgery Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy. n_ramacciotti@libero.it.ORCID http://orcid.org/0000-0001-7656-3676
Lorenzo PicciniGeneral and Peritoneal Surgery Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Erion RrekaGeneral and Peritoneal Surgery Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Piero Vincenzo LippolisGeneral and Peritoneal Surgery Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPeritoneal carcinomatosis (PC) presents a significant challenge and is often associated with poor prognosis. Cytoreductive surgery with heated intraperitoneal chemotherapy (CRS-HIPEC) stands as a well-established treatment modality for various forms of PC. The peritoneal cancer index (PCI) is used to assess the intraperitoneal disease burden, with evidence suggesting a linear correlation with overall survival, particularly in colorectal cancers with peritoneal metastasis. Similarly, completeness of cytoreduction (CC) is assessed post-resection to quantitatively measure residual disease in the abdomen. There has been a growing trend toward minimally invasive CRS-HIPEC, though achieving an accepted CC using this approach has been less frequently reported. This article describes the experience at our institution after ten cases of robotic-assisted CRS-HIPEC. MATERIALS AND

methodsData from the ten consecutive R-CRS-HIPEC were retrospectively collected. Comprehensive preoperative imaging and multidisciplinary team deliberations were conducted for case selection. Mini-invasive robotic CRS-HIPEC was considered only for patients exhibiting a limited amount of PC, as evidenced by prior laparoscopy (PCI < 10). To compare surgical outcomes with a homogeneous population of patients undergoing open CRS and HIPEC, 18 consecutive patients treated in the pre-robotic era were retrospectively included, all with PCI < 10 and histology consistent with appendiceal-origin neoplasms.

resultsNo perioperative complications were noted, and all patients were discharged within seven days of the operation.

conclusionsRobotic-assisted CRS-HIPEC for appendiceal mucinous neoplasms in highly selected patients is a safe and feasible procedure. A low intraperitoneal tumor burden in patients with intraperitoneal mucinous neoplasms emerges as a mandatory prerequisite to approach CRS-HIPEC with a robotic approach. We endorse ongoing investigation and future prospective clinical trials employing this technique.

Indexed as

CarcinomaCytoreduction Surgical ProceduresHyperthermic Intraperitoneal ChemotherapyPeritoneal NeoplasmsRobotic Surgical ProceduresAdultAgedCombined Modality TherapyFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeHIPECMinimally invasive surgeryPeritoneal carcinomatosisRobotic

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.