Evidence map›Paper›PMID 42265280›Full record

ArticleCommunications biology2026

P-STAT3-dependent SPP1 transcription in cholangiocytes drives hepatic stellate cells activation in congenital hepatic fibrosis.

Mengfan Jiao, Ye Sun, Rui Liu, Xizhi Yin, Xiaoxue Hou, Hui Yuan, Zixing Dai, Qingling Chen, Chuanlong Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mengfan JiaoDepartment of Infectious Disease, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Ye SunDepartment of Infectious Disease, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Rui LiuDepartment of Infectious Disease, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Xizhi YinDepartment of Infectious Disease, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Xiaoxue HouDepartment of Respiratory and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Hui YuanDepartment of Infectious Disease, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Zixing DaiDepartment of Infectious Disease, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Qingling ChenDepartment of Infectious Disease, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Chuanlong ZhuDepartment of Infectious Disease, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China. zhuchuanlong@jsph.org.cn.ORCID 0000-0001-6557-1654

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82472167
6 · The paper itself

Abstract

Congenital hepatic fibrosis (CHF) is a rare inherited liver disorder caused by mutations in the polycystic kidney and hepatic disease-1 gene (PKHD1), leading to progressive hepatic fibrosis. In our study, single-cell RNA sequencing of a CHF patient carrying compound heterozygous PKHD1 mutations revealed markedly intercellular communication between cholangiocytes and hepatic stellate cells (HSCs) via the secreted phosphoprotein 1 (SPP1)-integrin α8β1 axis. The CRISPR-Cas9-generated Pkhd1 knockout mouse model (Pkhd1

Indexed as

Hepatic Stellate CellsLiver CirrhosisOsteopontinSTAT3 Transcription FactorAnimalsBile DuctsDisease Models, AnimalGenetic Diseases, InbornHumansMaleMiceMice, KnockoutReceptors, Cell SurfaceSignal TransductionTranscription, GeneticOsteopontinPkhd1 protein, mouseReceptors, Cell SurfaceStat3 protein, mouseSTAT3 Transcription Factor

Identifiers

PMID42265280
PMCPMC13590539

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.