Evidence map›Paper›PMID 42265238›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Inverse correlation between acid reflux and dwell time of voice protheses (Provox

Daniel Runggaldier, Baselt Bastian, Naomi Iob, Cosima Riemenschnitter, Christian Thüring, Jérôme R Lechien, Jérôme Bonzon, Jörg E Bohlender, Grégoire B Morand

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Daniel RunggaldierDepartment of Otorhinolaryngology, Head & Neck Surgery, University Hospital Zurich, University of Zurich, Zürich, Switzerland. daniel.runggaldier@usz.ch.ORCID http://orcid.org/0000-0003-2428-897X
Baselt BastianDepartment of Otorhinolaryngology, Head & Neck Surgery, University Hospital Zurich, University of Zurich, Zürich, Switzerland.
Naomi IobDepartment of Otorhinolaryngology, Head & Neck Surgery, University Hospital Zurich, University of Zurich, Zürich, Switzerland.
Cosima RiemenschnitterDepartment of Otorhinolaryngology, Head & Neck Surgery, University Hospital Zurich, University of Zurich, Zürich, Switzerland.
Christian ThüringDepartment of Otorhinolaryngology, Head & Neck Surgery, University Hospital Zurich, University of Zurich, Zürich, Switzerland.
Jérôme R LechienDepartment of Surgery, Research Institute for Language Science and Technology, University of Mons, Mons, Belgium.
Jérôme BonzonDepartment of Otorhinolaryngology, Head & Neck Surgery, University Hospital Zurich, University of Zurich, Zürich, Switzerland.
Jörg E BohlenderDepartment of Otorhinolaryngology, Head & Neck Surgery, University Hospital Zurich, University of Zurich, Zürich, Switzerland.
Grégoire B MorandDepartment of Otorhinolaryngology, Head & Neck Surgery, University Hospital Zurich, University of Zurich, Zürich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the impact of extraesophageal acidic reflux and proton pump inhibitor (PPI) therapy on the dwell time of Provox

methodsThis is a retrospective review of prospectively recruited patients with total laryngectomy/ laryngopharyngectomy and rehabilitation with Provox

resultsTwenty-two patients were included. Regression analysis showed an inverse relationship between acid exposure and the average dwell time in days of the voice prostheses (β = -1.85, 95% CI: -2.90 to -0.80, p = 0.0014, R2 = 0.40 for pH < 6.5 resp. β = -1.74, 95% CI: -2.95 to -0.52, p = 0.0071, R2 = 0.30 for pH < 6.0). Twelve patients were on regular PPI treatment, 10 patients were off PPI. Patients with PPI usage did not show a significantly different acid exposure in the neopharynx. No difference in the dwell time between the patients with and without regular PPI therapy was observed.

conclusionIn our cohort, acid reflux exposure is inversely correlated with the dwell time of Provox

Indexed as

Gastroesophageal RefluxLaryngectomyLarynx, ArtificialPharyngectomyProton Pump InhibitorsAgedFemaleHumansHydrogen-Ion ConcentrationMaleMiddle AgedProspective StudiesRetrospective StudiesTime FactorsProton Pump InhibitorsExtraesophageal refluxLaryngectomyPPIProton pump inhibitorsProvox voice prosthesis

Identifiers

PMID42265238

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.