Evidence map›Paper›PMID 42265210›Full record

ArticleNature methods2026

OrthoFinder: improved phylogenetic orthology inference with enhanced accuracy and scalability.

David M Emms, Yi Liu, Laurence Belcher, Jonathan Holmes, Steven Kelly

Erratum issuedAbstract read
In one paragraph

Article in Nature methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Multifaceted and evolutionarily dynamic interactions betweenbioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

David M EmmsDepartment of Biology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-9065-8978
Yi LiuDepartment of Biology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0009-0000-2084-7776
Laurence BelcherDepartment of Biology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-2392-6503
Jonathan HolmesDepartment of Biology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0009-0001-0440-8404
Steven KellyDepartment of Biology, University of Oxford, Oxford, UK. steven.kelly@biology.ox.ac.uk.ORCID http://orcid.org/0000-0001-8583-5362

Funding

Wellcome TrustWellcome Trust (Wellcome) 226598/Z/22/Z
6 · The paper itself

Abstract

Here we present a major advancement of the OrthoFinder method. This extends OrthoFinder's high-accuracy comparative genomic framework to provide substantially enhanced scalability and accuracy. Specifically, we show that enhanced phylogenetic delineation of orthogroups provides a 7% relative increase in orthogroup inference accuracy. We further demonstrate that a new gene assignment method substantially reduces overall runtime RAM usage without compromising accuracy. The latest version of OrthoFinder is available via GitHub at https://github.com/OrthoFinder/OrthoFinder .

Indexed as

GenomicsPhylogenySoftwareAlgorithmsAnimals

Identifiers

PMID42265210
PMCPMC13346109

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.