Evidence map›Paper›PMID 42265199›Full record

Observational studyScientific reports2026

The eGFR difference between creatinine-based and cystatin-C-based equations is also important in an Asian population within the J-CKD-DB-Ex.

Takaya Nakashima, Hajime Nagasu, Akira Hirano, Masao Iwagami, Tadahiro Goto, Naoki Kashihara, Masaomi Nangaku, Yosuke Hirakawa

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Takaya NakashimaDepartment of Anesthesiology and Intensive Care Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Hajime NagasuDepartment of Nephrology and Hypertension, Kawasaki Medical School, Okayama, Japan.
Akira HiranoDepartment of Nephrology and Hypertension, Kawasaki Medical School, Okayama, Japan.
Masao IwagamiSocial Medicine Group, Department of Digital Health, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Tadahiro GotoTXP Medical Co. Ltd, Tokyo, Japan.
Naoki KashiharaKawasaki Medical School, Kawasaki Geriatric Medical Center, Okayama, Japan.
Masaomi NangakuDivision of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yosuke HirakawaDivision of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. yhirakawa@g.ecc.u-tokyo.ac.jp.

Funding

Japan Agency for Medical Research and Development 25tm0424230h0002
6 · The paper itself

Abstract

Recent studies have shown that a large negative estimated glomerular filtration rate (eGFR) difference (eGFRdiff), defined as the cystatin C-based eGFR minus the creatinine-based eGFR, is related with kidney events. However, whether this association applies to the Japanese population remains unclear. This study assessed the importance of a negative eGFRdiff in the Japanese population. This was a retrospective cohort study using the J-CKD-DB-Ex. The association between baseline eGFRdiff and kidney composite outcome defined as progression to CKD stage G5 (eGFRcr < 15 mL/min/1.73 m

Indexed as

CreatinineCystatin CEast Asian PeopleGlomerular Filtration RateRenal Insufficiency, ChronicAgedDisease ProgressionFemaleHumansJapanMaleMiddle AgedProportional Hazards ModelsRetrospective StudiesCreatinineCystatin CChronic kidney diseaseCreatinineCystatin CeGFR difference

Identifiers

PMID42265199
PMCPMC13494015

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.