Evidence map›Paper›PMID 42265188›Full record

ArticleScientific reports2026

Evaluation of a human 3D multi-spheroid model derived from SH-SY5Y cells for cytotoxicity testing.

Lenka Ticha, Jan Capek, Antonin Vlcek, Pavlina Nyvltova, Stepanka Jelinkova, Jiri Handl, Tomas Rousar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lenka TichaDepartment of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentska 573, Pardubice, 532 10, Czech Republic.ORCID http://orcid.org/0009-0007-6107-8345
Jan CapekDepartment of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentska 573, Pardubice, 532 10, Czech Republic.ORCID http://orcid.org/0000-0002-3713-2467
Antonin VlcekDepartment of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentska 573, Pardubice, 532 10, Czech Republic.ORCID http://orcid.org/0009-0001-0094-5755
Pavlina NyvltovaDepartment of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentska 573, Pardubice, 532 10, Czech Republic.ORCID http://orcid.org/0000-0002-4544-6407
Stepanka JelinkovaDepartment of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentska 573, Pardubice, 532 10, Czech Republic.ORCID http://orcid.org/0009-0002-7514-8627
Jiri HandlDepartment of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentska 573, Pardubice, 532 10, Czech Republic. jiri.handl@upce.cz.
Tomas RousarDepartment of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentska 573, Pardubice, 532 10, Czech Republic.ORCID http://orcid.org/0000-0002-6893-821X

Funding

Ministerstvo Školství, Mládeže a Tělovýchovy CZ.02.01.01/00/23_021/0008439
6 · The paper itself

Abstract

3D culture models have been extensively used in cell testing. Thus, we aimed to develop a novel cellular model of multiple spheroids derived from neuronal SH-SY5Y cells. We observed that poly-D-lysine coating can induce formation of a population of spheroids, i.e. the density of 20 × 10

Indexed as

Cell Culture TechniquesCell Culture Techniques, Three DimensionalSpheroids, CellularToxicity TestsCadmium ChlorideCell Line, TumorCell SurvivalGlutathioneHumansCadmium ChlorideGlutathioneMulti-spheroid modelNeurotoxicity assessmentPoly-D-lysineSH-SY5Y cellsThree-dimensional cell culture

Identifiers

PMID42265188
PMCPMC13493907

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.