ArticleScientific reports2026
Marine macroalgae-mediated ultrasonic-assisted green synthesis of CuO nanoparticles embedded in starch/PVA electrospun nanoscaffolds for in vitro α-amylase and α-glucosidase inhibitory activity.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Diabetes mellitus is a rapidly growing metabolic disorder that requires effective and sustainable therapeutic strategies to manage postprandial hyperglycemia. In recent years, green synthesis of metal oxide nanoparticles has emerged as a promising approach due to its eco-friendly nature, cost-effectiveness, and enhanced biocompatibility. Among these, copper oxide nanoparticles (CuO NPs) have gained attention for their potential in inhibiting key carbohydrate-hydrolyzing enzymes involved in glucose metabolism. In this study, CuO NPs were synthesized via an ultrasonic-assisted green method using Chondracanthus exasperatus marine macroalgae extract and subsequently incorporated into starch/polyvinyl alcohol electrospun nanofibrous scaffolds to develop a novel nanocomposite system. The synthesized nanoparticles and scaffolds were comprehensively characterized using UV-Vis spectroscopy, FTIR, XRD, SEM, TGA, and DLS analyses, confirming successful nanoparticle formation, phytochemical capping, uniform dispersion, and enhanced thermal stability. The antidiabetic potential of the developed system was evaluated through in vitro α-amylase and α-glucosidase inhibition assays. The nanoscaffolds exhibited significant inhibitory activity (α-amylase: 81.18% and α-glucosidase: 79.12% at 100 µg/mL) compared to CuO NPs and algal extract alone. The IC
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