Evidence map›Paper›PMID 42265093›Full record

ArticleNature communications2026

Prefrontal parvalbumin neurons mediate working memory in a task demand-dependent manner.

Tyler D Dexter, Meira M F Machado, Shahnaza Hamidullah, Daniel Palmer, Ahmed M Hashad, Marcus Doyle, Megan Attard, Brian L Allman, Wataru Inoue, Lisa M Saksida and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tyler D DexterNeuroscience Program, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada. tydexter@health.ucsd.edu.ORCID 0009-0009-4127-2022
Meira M F MachadoDepartment of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.ORCID 0000-0003-4619-5782
Shahnaza HamidullahNeuroscience Program, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Daniel PalmerDepartment of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.ORCID 0000-0002-3419-8647
Ahmed M HashadDepartment of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Marcus DoyleNeuroscience Program, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Megan AttardNeuroscience Program, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Brian L AllmanDepartment of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Wataru InoueDepartment of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.ORCID 0000-0002-2438-5123
Lisa M SaksidaDepartment of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.ORCID 0000-0002-8416-8171
Timothy J BusseyDepartment of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.ORCID 0000-0002-3180-3709

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) 426966Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) PJT 426966Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada) 2019-06102 and 2019-06087Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada) RGPIN-2019-06087
6 · The paper itself

Abstract

The prefrontal cortex (PFC) is known to mediate working memory processes, although how individual circuit elements within PFC support working memory is much less well understood. Parvalbumin-expressing neurons (PVNs) are inhibitory cells involved in coordinating local communication and facilitate the emergence of high frequency gamma oscillations. PVNs are shown to support various PFC-dependent cognitive functions in rodents, though reports of their involvement in working memory have yielded conflicting results. Here, we implemented in vivo fiber photometry and optogenetics to record and manipulate prefrontal PVN activity during a touchscreen-based test of working memory in mice. We found that PVN involvement is highly dependent on task demands, making a necessary contribution through heightened activity only during high-demand conditions. These findings suggest that previous contradictory findings regarding the role of prefrontal PVNs in working memory may be due to differences in the degree to which the working memory paradigms used taxed cognitive load.

Indexed as

Memory, Short-TermNeuronsParvalbuminsPrefrontal CortexAnimalsCognitionGamma RhythmMaleMiceMice, Inbred C57BLOptogeneticsParvalbumins

Identifiers

PMID42265093
PMCPMC13402680

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.