Evidence map›Paper›PMID 42265084›Full record

ArticleNature communications2026

Adaptive Riemannian optimization for multi-scale diffeomorphic matching.

Rohit Jena, Pratik Chaudhari, James C Gee

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Brainana: an end-to-end preprocessing framework for macaque neuroimaging.bioRxiv : the preprint server for biology · 2026
    Article
  4. The feasibility of [Cancer imaging : the official publication of the International Cancer Imaging Society · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. PolyPose: Deformable 2D/3D Registration via Polyrigid Transformations.Advances in neural information processing systems · 2025
    Article
  12. Article
  13. Fast segmentation with the NextBrain histological atlas.bioRxiv : the preprint server for biology · 2025
    Article
  14. Gaussian primitives for deformable image registration.Physics and imaging in radiation oncology · 2025
    Article
  15. Streamlining 4D Cardiac Image Workflows: Open-Source Tools for Segmentation, Registration, and Visualization.Functional imaging and modeling of the heart : ... International Workshop, FIMH ..., proceedings. FIMH (Conference) · 2025
    Article
  16. MultiMorph: On-demand Atlas Construction.Proceedings. IEEE Computer Society Conference on Computer Vision and Pattern Recognition · 2025
    Article
  17. Fast segmentation with the NextBrain histological atlas.Imaging neuroscience (Cambridge, Mass.)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rohit JenaComputer and Information Science, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-8707-383X
Pratik ChaudhariComputer and Information Science, University of Pennsylvania, Philadelphia, PA, USA. pratikac@upenn.edu.ORCID 0000-0003-4590-1956
James C GeeComputer and Information Science, University of Pennsylvania, Philadelphia, PA, USA. gee@upenn.edu.ORCID 0000-0002-2258-0187

Funding

Multi-scale and multi-modality imaging of neuropathology in VCIDU24NS135568 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JAMES C GEE, Yulin Ge · 2023 to 2026
$6.6M
Advanced Normalization ToolsR01EB031722 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI GEE, JAMES C · 2022 to 2025
$2.7M
NIBIB NIH HHS R01 EB031722NINDS NIH HHS U24 NS135568U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01-EB031722U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01-HL133889U.S. Department of Health & Human Services | National Institutes of Health (NIH) RF1-MH124605U.S. Department of Health & Human Services | National Institutes of Health (NIH) U24-MH114827U.S. Department of Health & Human Services | National Institutes of Health (NIH) U24-NS135568
6 · The paper itself

Abstract

Image matching is a fundamental task in quantitative biomedical and biological image analyses, enabling researchers to compare, integrate, and interpret imaging data across subjects, time points, modalities, and experimental conditions. Existing state-of-the-art registration methods are slow due to inefficient implementations and poor convergence rates because of the ill-conditioned nature of the optimization problem. Deep learning methods offer fast inference but require extensive training time, substantial inference memory, and fail to generalize across long-tailed distributions or diverse image modalities, necessitating costly retraining. We address these challenges by proposing FireANTs, a training-free, GPU-accelerated, multi-scale adaptive Riemannian optimization algorithm for fast and accurate dense diffeomorphic image matching. FireANTs more than doubles the speed of the community standard ANTs registration tool on a CPU, and is two orders of magnitude faster on a GPU. On the GPU, FireANTs performs competitively with deep learning methods on inference runtime while consuming up to 10 × less memory. FireANTs demonstrates robustness on a wide variety of matching problems across modalities, species, and organs, without any domain-specific training or tuning. Our framework allows hyperparameter grid search studies with less resources and time compared to traditional and deep learning registration algorithms alike.

Indexed as

Adaptive AlgorithmsImage Processing, Computer-AssistedAnimalsDeep LearningHumans

Identifiers

PMID42265084
PMCPMC13249883

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.