Evidence map›Paper›PMID 42265027›Full record

Observational studyBritish journal of anaesthesia2026

Differential associations between preoperative anaemia and postoperative outcomes in women and men undergoing surgery

Ethan H Crispell, Germán J Medina-Rincon, Juan Jose Morales Behaine, Andrew C Hanson, Kellie A Robbins, Denis Snegovskikh, Matthew A Warner

Abstract readObservational Study
In one paragraph

Observational study in British journal of anaesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Ethan H CrispellDepartment of Anesthesiology and Perioperative Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Germán J Medina-RinconDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
Juan Jose Morales BehaineDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
Andrew C HansonDepartment of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Kellie A RobbinsAnesthesia Clinical Research Unit, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
Denis SnegovskikhDepartment of Anesthesiology, Rush University Medical Center, Chicago, IL, USA.
Matthew A WarnerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA; Patient Blood Management Program, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address: warner.matthew@mayo.edu.

Funding

Attenuation of Anemia for the Optimization of Post-Hospitalization Functional Recovery in Survivors of Critical IllnessK23HL153310 · NHLBI · MAYO CLINIC ROCHESTER · PI WARNER, MATTHEW A · 2021 to 2025
$909k
NHLBI NIH HHS K23 HL153310
6 · The paper itself

Abstract

backgroundPreoperative anaemia is associated with adverse surgical outcomes, yet it is unclear whether anaemia-outcome relationships are consistent for women and men.

methodsThis observational cohort study was conducted between August 1, 2012 and July 31, 2022 in adults undergoing surgery requiring postoperative hospitalisation at a large academic medical centre in the USA. Anaemia was defined as haemoglobin <12 g dl

resultsOf 228 341 procedures (49.4% among women) included, AKI occurred in 13.2% overall, with a lower rate in women (7.6% in women vs 18.8% in men). Preoperative anaemia was present in 70 968 (31.1%) patients, including 30.8% of women and 31.4% of men. In adjusted analyses, increasing severity of preoperative anaemia was associated with worse outcomes. When comparing severe preoperative anaemia to no anaemia, the adjusted odds ratio (OR) for AKI was 2.91 (95% confidence interval: 2.47, 3.44) in women vs 1.43 (1.22, 1.68) in men. Corresponding ORs were 2.48 (2.14, 2.88) vs 1.62 (1.40, 1.86) for ischaemic events, and 4.78 (3.94, 5.80) vs 2.62 (2.13, 3.23) for surgical site infection. Interaction testing confirmed stronger associations in women for AKI, ischaemic events, and surgical site infection (all interaction P<0.001).

conclusionsPreoperative anaemia is associated with adverse outcomes in both women and men, though the associations with acute kidney injury, ischaemic events and surgical site infection are stronger in women.

Indexed as

Acute Kidney InjuryAnemiaPostoperative ComplicationsAdultAgedCohort StudiesFemaleHumansMaleMiddle AgedPreoperative PeriodSex FactorsTreatment Outcomeacute kidney injurygenderhaemoglobinperioperative medicinepreoperative anaemiatransfusion

Identifiers

PMID42265027
PMCPMC13359043

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