Evidence map›Paper›PMID 42264881›Full record

Observational studyBMJ open respiratory research2026

The

Tina Hartert, Christian Rosas-Salazar, Dawn C Newcomb, Brittney M Snyder, Sergejs Berdnikovs, Christopher McKennan, Sarah Osmundson, Zhouwen Liu, Erica Tafoya, Wais Folad and 9 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Tina HartertDepartment of Medicine, Center for Asthma Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA tina.hartert@vumc.org.ORCID http://orcid.org/0000-0001-7470-1166
Christian Rosas-SalazarDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Dawn C NewcombDepartment of Medicine, Center for Asthma Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Brittney M SnyderObstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Sergejs BerdnikovsDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Christopher McKennanDepartment of Statistics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Sarah OsmundsonDepartment of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Zhouwen LiuDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Erica TafoyaDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Wais FoladDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Pat SimonDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Sara ReissDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Kadijah PoleonDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jacqueline-Yvonne CephusDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Shelby N KuehnleDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Kaitlin E McKernanDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Siyuan MaDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Larry J AndersonDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Tebeb GebretsadikDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Funding

Viral and Host Determinants of Infant and Childhood Allergy and AsthmaU19AI095227 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Tina V Hartert · 2011 to 2026
$34.9M
NIAID NIH HHS U19 AI095227
6 · The paper itself

Abstract

introductionThe airway epithelial barrier continues to develop during the first year of life, representing a critical time window of susceptibility to the effects of respiratory viruses that may contribute to the development of childhood asthma. This study specifically aimed to assess the impact of respiratory syncytial virus (RSV) infection on the longitudinal development of the airway epithelium, airway metabolism, DNA methylation and subsequent childhood asthma. METHODS AND ANALYSIS: The ETHICS AND DISSEMINATION: This study has been approved by the Vanderbilt University Medical Center IRB (#222277), and study results will be communicated in peer-reviewed publications and to the study participants and lay community. By analysing these longitudinal multi-omic datasets, we aim to uncover key mechanisms driving airway epithelial development and identify how these processes are altered by early-life RSV infection and contribute to the development of early-life respiratory morbidity and asthma.

Indexed as

AsthmaRespiratory MucosaRespiratory SoundsRespiratory Syncytial Virus InfectionsRespiratory Tract InfectionsBirth CohortChild, PreschoolFemaleHumansInfantInfant, NewbornMalePregnancyProspective StudiesResearch DesignAirway EpitheliumAsthmaAsthma EpidemiologyAsthma MechanismsViral infection

Identifiers

PMID42264881
PMCPMC13264850

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.