Evidence map›Paper›PMID 42264628›Full record

ReviewJACC. Cardiovascular interventions2026

Aortic Valve Leaflet Modification: A Working Group Position Statement on Best Practices and Step-by-Step Guide.

Toby Rogers, Rim N Halaby, Adam B Greenbaum, Christopher G Bruce, Vasilis C Babaliaros, Jaffar M Khan, Mohamed Abdel-Wahab, Matti Adam, Nicholas S Amoroso, Ole de Backer and 34 more

Abstract readReview
In one paragraph

Review in JACC. Cardiovascular interventions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors.

Toby RogersMedstar Washington Hospital Center and Georgetown University, Washington, District of Columbia, USA; Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Rim N HalabyDivision of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA; Structural Heart and Valve Center, Emory University Hospital, Atlanta, Georgia, USA.
Adam B GreenbaumStructural Heart and Valve Center, Emory University Hospital, Atlanta, Georgia, USA.
Christopher G BruceDivision of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA; WellSpan Health York Hospital, York, Pennsylvania, USA.
Vasilis C BabaliarosStructural Heart and Valve Center, Emory University Hospital, Atlanta, Georgia, USA.
Jaffar M KhanSt. Francis Hospital, Roslyn, New York, USA.
Mohamed Abdel-WahabHeart Center Leipzig at Leipzig University, Leipzig, Germany.
Matti AdamUniversity Hospital Cologne, Cologne, Germany.
Nicholas S AmorosoMedical University of South Carolina, Charleston, South Carolina, USA.
Ole de BackerThe Heart Center, Rigshospitalet, Copenhagen, Denmark.
Israel M BarbashChaim Sheba Medical Center, Ramat Gan, Israel.
Isida BykuStructural Heart and Valve Center, Emory University Hospital, Atlanta, Georgia, USA.
Kwong-Yue Eric ChanDepartment of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Department of Medicine, Queen Mary Hospital, Hong Kong, China; Cardiac Medical Unit, Grantham Hospital, Hong Kong, China.
Adnan K ChhatriwallaSaint Luke's Mid America Heart Institute, Kansas City, Missouri, USA.
Christine J ChungDepartment of Cardiology, University of Washington School of Medicine, Seattle, Washington, USA.
James CockburnUniversity Hospital Sussex NHS Foundation Trust, Brighton, United Kingdom.
Jeremiah P DeptaMedical College of Wisconsin, Milwaukee, Wisconsin, USA.
David ElisonDepartment of Cardiology, University of Washington School of Medicine, Seattle, Washington, USA.
Marvin EngUniversity of Nebraska, Omaha, Nebraska, USA.
Jason R FoerstCarilion Clinic, Roanoke, Virginia, USA.
Phillip FreemanKarolinska University Hospital, Stockholm, Sweden.
David Hildick-SmithUniversity Hospital Sussex NHS Foundation Trust, Brighton, United Kingdom.
Amar KrishnaswamyCleveland Clinic, Cleveland, Ohio, USA.
Roger J LahamBeth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Simon C LamDepartment of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Department of Medicine, Queen Mary Hospital, Hong Kong, China.
M Azeem LatibMontefiore Medical Center, Bronx, New York, USA.
Paul D MahoneyEast Carolina University, Greenville, North Carolina, USA.
James M McCabeBeth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Kamran MuhammadOklahoma Heart Institute, Tulsa, Oklahoma, USA.
Emily M PerdoncinKaiser-Permanente, San Francisco, California, USA.
Karl K PoonCardiology Program, Prince Charles Hospital, University of Queensland, Brisbane, Australia.
Andrei M PopAscension Alexian Brothers Hospital, Elk Grove Village, Illinois, USA.
Mark J RicciardiEndeavor Health NorthShore, Evanston, Illinois, USA.
Jeremy RierWellSpan Health York Hospital, York, Pennsylvania, USA.
John T SaxonUniversity of Virginia, Charlottesville, Virginia, USA.
Stephanie SellersCardiovascular Translational Laboratory, University of British Columbia, Vancouver, British Columbia, Canada; St. Paul's Hospital, Vancouver, British Columbia, Canada; Dilawri Cardiovascular Institute, Vancouver General Hospital, Vancouver, British Columbia, Canada.
Puvi N SeshiahThe Christ Hospital, Cincinnati, Ohio, USA.
Pinak B ShahMass General Brigham, Boston, Massachusetts, USA.
Pedro A VillablancaHenry Ford Hospital, Detroit, Michigan, USA.
Brian K WhisenantIntermountain Health, Riverton, Utah, USA.
Chun-Ka WongDepartment of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Department of Medicine, Queen Mary Hospital, Hong Kong, China.
Pradeep K YadavPiedmont Hospital, Atlanta, Georgia, USA.
D Korel YildirimDivision of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Robert J LedermanDivision of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: lederman@nih.gov.

Funding

Novel catheter treatment of valve diseaseZIAHL006040 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEDERMAN, ROBERT J · 2010 to 2025
$23.6M
MRI catheter design and fabricationZIAHL006041 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEDERMAN, ROBERT J · 2014 to 2025
$12.2M
Intramural NIH HHS ZIA HL006040Intramural NIH HHS ZIA HL006041
6 · The paper itself

Abstract

Coronary artery obstruction is a potential life-threatening complication of transcatheter aortic valve replacement (TAVR) in all settings including native, valve-in-valve, and redo-TAVR. Risk of obstruction can be identified on preprocedural computed tomography. BASILICA (bioprosthetic or native aortic scallop intentional laceration to prevent iatrogenic coronary artery obstruction) effectively prevents TAVR-induced coronary obstruction. Perceived technical complexity, limited availability of purpose-built devices, and scarce training opportunities have hindered the adoption of BASILICA and related techniques. This document synthesizes international experience to provide contemporary best-practice guidance for BASILICA and related leaflet modification strategies. This state-of-the-art review details transcatheter electrosurgery principles; how to determine risk and computed tomographic risk analysis and plan the procedures; a step-by-step guide to electrosurgical BASILICA; tips and tricks for uncommon challenges; scenarios in which BASILICA is unlikely to succeed; and variant techniques such as intraleaflet valve deployment, alternative measures, and dedicated devices. These contemporary best practices can help operators gain or maintain proficiency.

Indexed as

Aortic ValveAortic Valve StenosisBioprosthesisCoronary StenosisElectrosurgeryHeart Valve ProsthesisTranscatheter Aortic Valve ReplacementConsensusHumansProsthesis DesignRisk AssessmentRisk FactorsTreatment OutcomeBASILICAcomputed tomographycoronary artery obstructionleaflet modificationtranscatheter aortic valve replacementtranscatheter electrosurgery

Identifiers

PMID42264628
PMCPMC13405200

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.