Evidence map›Paper›PMID 42264156›Full record

ArticleGigaScience2026

A large dataset of brain imaging linked to health systems data: curation and access to a whole system national cohort from NHS Scotland.

Michael P J Camilleri, Dorian Gouzou, Salim Al-Wasity, Muthu R K Mookiah, María Valdes Hernandez, Bea Alex, Sotirios A Tsaftaris, Andrew Brooks, Ruairidh MacLeod, Honghan Wu and 11 more

Abstract readDataset
In one paragraph

Article in GigaScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Michael P J CamilleriComputing, School of Science and Engineering, University of Dundee, Dundee, DD1 4HN, UK.ORCID 0000-0002-8619-3231
Dorian GouzouInstitute for Neuroscience and Cardiovascular Research, School of Medicine, University of Edinburgh, EH16 4TJ, UK.ORCID 0000-0003-4865-7784
Salim Al-WasitySchool of Medicine, Ninewells NHS and University Hospital, Dundee, DD2 1GZ, UK.ORCID 0000-0002-6762-8324
Muthu R K MookiahSchool of Medicine, Ninewells NHS and University Hospital, Dundee, DD2 1GZ, UK.ORCID 0000-0001-6437-1482
María Valdes HernandezInstitute for Neuroscience and Cardiovascular Research, School of Medicine, University of Edinburgh, EH16 4TJ, UK.ORCID 0000-0003-2771-6546
Bea AlexSchool of Informatics, University of Edinburgh, Edinburgh, EH8 9AB, UK.ORCID 0000-0002-7279-1476
Sotirios A TsaftarisSchool of Engineering, University of Edinburgh, Edinburgh, EH9 3JL, UK.ORCID 0000-0002-8795-9294
Andrew BrooksEdinburgh Parallel Computing Centre, University of Edinburgh, Edinburgh, EH8 9BT, UK.ORCID 0000-0002-8837-3201
Ruairidh MacLeodEdinburgh Parallel Computing Centre, University of Edinburgh, Edinburgh, EH8 9BT, UK.ORCID 0000-0002-2641-2543
Honghan WuUsher Institute, School of Medicine, University of Edinburgh, Edinburgh, EH16 4UX, UK.ORCID 0000-0002-0213-5668
Brenda BauerInstitute for Neuroscience and Cardiovascular Research, School of Medicine, University of Edinburgh, EH16 4TJ, UK.ORCID 0000-0002-1417-1260
Claire GroverSchool of Informatics, University of Edinburgh, Edinburgh, EH8 9AB, UK.ORCID 0000-0001-7019-1250
Parminder ReelHealth Informatics Centre, School of Medicine, University of Dundee, Dundee, DD2 1FD, UK.
Susan KruegerHealth Informatics Centre, School of Medicine, University of Dundee, Dundee, DD2 1FD, UK.ORCID 0000-0002-5219-1959
Richard TobinSchool of Informatics, University of Edinburgh, Edinburgh, EH8 9AB, UK.ORCID 0000-0003-4050-7888
J Douglas SteeleSchool of Medicine, Ninewells NHS and University Hospital, Dundee, DD2 1GZ, UK.ORCID 0000-0002-9822-8753
Grant MairInstitute for Neuroscience and Cardiovascular Research, School of Medicine, University of Edinburgh, EH16 4TJ, UK.ORCID 0000-0003-2189-443X
Joanna WardlawInstitute for Neuroscience and Cardiovascular Research, School of Medicine, University of Edinburgh, EH16 4TJ, UK.ORCID 0000-0002-9812-6642
Alexander DoneyCardiovascular Research, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK.ORCID 0000-0002-6210-5620
Emanuele TruccoComputing, School of Science and Engineering, University of Dundee, Dundee, DD1 4HN, UK.ORCID 0000-0002-5055-0794
William WhiteleyInstitute for Neuroscience and Cardiovascular Research, School of Medicine, University of Edinburgh, EH16 4TJ, UK.ORCID 0000-0002-4816-8991

Funding

University of Edinburgh
6 · The paper itself

Abstract

backgroundWe present the design and implementation of a data curation framework to generate a large-scale clinical brain imaging dataset suitable for artificial intelligence (AI) enabled image analysis.

findingsThe dataset is accessible through the Brain Health Data (BHD) initiative, which includes ~417,341 magnetic resonance imaging (MRI) and 846,077 computerized tomography head studies, linked electronic health records, and associated free-text imaging reports from clinical practice between 2010 and 2018 in Scotland, exceeding 185 TB in size. The data curation framework was developed during the SCottish AI in Neuroimaging to Predict Dementia and Neurodegenerative Disease (SCANDAN) study, which used a subset of 41,966 MRI series from the BHD for dementia prediction.We describe the processing of the BHD metadata and our multilabel classification output. We discuss the strengths of the BHD, including clinical relevance thanks to its unprecedented scale, population-wide representativeness of a national free-at-the-point-of-delivery healthcare, long-term follow-up to neurodegenerative disease, and real-world variability. We describe the challenges and lessons learnt in developing a framework to curate data, including the time needed to obtain permissions, the need for easily accessible, secure, responsive and affordable computational environments, the variability of clinical data, and the challenge of extracting linked clinical data and images at scale.

conclusionThis resource will be crucial for clinical research, fostering the development of personalized medicine approaches, and fast-tracking the implementation of AI models in clinical workflows. We encourage the use of the BHD data through a streamlined application to the Public Benefit and Privacy Panel for Health and Care via the electronic Data Research and Innovation Service of Public Health Scotland (eDRIS).

Indexed as

BrainData CurationNeuroimagingArtificial IntelligenceDementiaElectronic Health RecordsHumansMagnetic Resonance ImagingNeurodegenerative DiseasesScotlandTomography, X-Ray Computedartificial intelligenceCThealthcare dataMRIneuroimaging

Identifiers

PMID42264156
PMCPMC13347094

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.