Evidence map›Paper›PMID 42263718›Full record

ReviewThe Lancet. Infectious diseases2026

Calciphylaxis complicated by NDM-1-producing Pseudomonas aeruginosa: first experience with cefepime-zidebactam alongside phage therapy in the USA.

Erlinda R Ulloa, Daniel Jaffurs, M Tuan Tran, Carol Lin, Hung Tran, Dorian Chan, Ali Nael, Sagar U Nigwekar, Mikeljon P Nikolich, Daria Van Tyne

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Lancet. Infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Erlinda R UlloaDivision of Infectious Diseases, Children's Hospital of Orange County, Orange, CA, USA; Department of Pediatrics, University of California Irvine School of Medicine, Irvine, CA, USA. Electronic address: chulie.ulloa@uci.edu.
Daniel JaffursDepartment of Plastic Surgery, Children's Hospital of Orange County, Orange, CA, USA.
M Tuan TranDivision of Infectious Diseases, Children's Hospital of Orange County, Orange, CA, USA.
Carol LinDivision of Oncology, Children's Hospital of Orange County, Orange, CA, USA.
Hung TranDivision of Oncology, Children's Hospital of Orange County, Orange, CA, USA.
Dorian ChanDivision of Oncology, Children's Hospital of Orange County, Orange, CA, USA.
Ali NaelDepartment of Pathology, Children's Hospital of Orange County, Orange, CA, USA.
Sagar U NigwekarDivision of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Mikeljon P NikolichWound Infections Department, Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Daria Van TyneDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Evolutionary Biology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Funding

Institute for Clinical and Translational ScienceUM1TR004927 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAN M COOPER, Eric J. Vilain · 2024 to 2026
$12.2M
Beta-Lactamase Inhibitors Sensitize Multidrug-Resistant Gram-negative Pathogens to Innate Immune ClearanceK08AI151253 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI ULLOA, ERLINDA ROSE · 2020 to 2024
$1.0M
NCATS NIH HHS UM1 TR004927NIAID NIH HHS K08 AI151253
6 · The paper itself

Abstract

We report a case of calciphylaxis-a rare vasculopathy characterised by arteriolar calcification and ischaemic skin necrosis-in a young woman with acute myeloid leukaemia. Her ulcerated skin lesions became superinfected with a pan-resistant New Delhi metallo-β-lactamase-1-producing Pseudomonas aeruginosa. Although such infections in the USA have largely been associated with international travel, our patient harboured one of the earliest domestically acquired isolates. Management required novel therapeutic strategies, including the first use of cefepime-zidebactam in the USA alongside bacteriophage therapy and calciphylaxis-directed treatment. This case highlights the diagnostic complexity of calciphylaxis in atypical populations and shows the potential for innovative therapeutic approaches to achieve favourable outcomes in this rare, potentially fatal condition.

Indexed as

Anti-Bacterial AgentsAzabicyclo CompoundsAzetidinesbeta-LactamasesCalciphylaxisCephalosporinsPhage TherapyPiperidinesPseudomonas aeruginosaPseudomonas InfectionsCefepimeCyclooctanesDrug CombinationsFemaleHumansThird Generation CephalosporinsAnti-Bacterial AgentsAzabicyclo CompoundsAzetidinesbeta-lactamase NDM-1beta-LactamasesCefepimecefepime-zidebactamCephalosporinsCyclooctanesDrug CombinationsPiperidinesThird Generation Cephalosporins

Identifiers

PMID42263718
PMCPMC13459741

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.