Evidence map›Paper›PMID 42263129›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

A fungal natural product that inhibits plant cellulose biosynthesis by disrupting cellulose synthase complexes.

Zhongshou Wu, Lu Liu, Wenyu Han, Xingbo Cai, Pixian Xiao, Zuodong Sun, Chunsheng Yan, Silvana Reid, Yun Chen, Zhonghua Ma and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhongshou Wu *State Key Laboratory of Rice Biological Breeding, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China.
Lu Liu *State Key Laboratory of Rice Biological Breeding, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China.
Wenyu Han *Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095.
Xingbo CaiDepartment of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA 90095.
Pixian XiaoState Key Laboratory of Rice Biological Breeding, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China.
Zuodong SunDepartment of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, CA 90095.
Chunsheng YanDepartment of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, CA 90095.
Silvana ReidDepartment of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095.
Yun ChenState Key Laboratory of Rice Biological Breeding, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-5663-2352
Zhonghua MaState Key Laboratory of Rice Biological Breeding, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-5426-0997
Yi TangDepartment of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095.
Steven E JacobsenDepartment of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA 90095.

Funding

Agricultural science and technology major project Agricultural Science and Technology Major ProjectCenter for Hierarchical Manufacturing, NSF (CHM, NSF) 2434499fundamental research funds for the central universities of Zhejiang University 226-2025-00083USDA | National Institute of Food and Agriculture (NIFA) 2021-67013-34259
6 · The paper itself

Abstract

Cellulose, a primary component of plant cell walls, is synthesized by cellulose synthase complexes (CSCs) at the plasma membrane. Targeting this process with cellulose biosynthesis inhibitors (CBIs) has significantly advanced our understanding of plant cell wall formation and provided valuable compounds for herbicide development. Here, we identified a fungal natural product, 8-methyldichlorodiaporthin (MDD), as a broad-spectrum plant CBI. Structure-activity relationship analyses demonstrate that methylation modifications on the isocoumarin ring and chlorination of the side chain are crucial for MDD-induced growth inhibition. A chemical forward genetic screen in

Indexed as

ArabidopsisArabidopsis ProteinsBiological ProductsCelluloseGlucosyltransferasesXanthinesCell WallHerbicidesMutationStructure-Activity RelationshipArabidopsis ProteinsBiological ProductsCellulosecellulose synthaseCESA1 protein, ArabidopsisGlucosyltransferasesHerbicidesXanthinescellulose biosynthesis inhibitorscellulose synthase complexesmultiherbicide resistancenatural compound

Identifiers

PMID42263129
PMCPMC13273347

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.