ReviewAnnals of nutrition & metabolism2026
Inflammation and Chronic Disease: The Mediterranean Diet in Precision and Personalized Nutrition.
Review in Annals of nutrition & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
<p>Background: Low-grade chronic inflammation (LGCI) is a shared biological pathway for noncommunicable chronic diseases (NCDs) and clinical manifestations, including atherosclerotic cardiovascular disease, type 2 diabetes, obesity-related complications, some cancers, and neurodegenerative conditions. Diet is a powerful modulator of inflammatory status. Summary: This review synthesizes mechanistic and clinical evidence linking LGCI to NCDs, with emphasis on the role of the Mediterranean dietary (MedDiet) pattern, and outlines pragmatic prescription guidelines within precision and personalized nutrition. Meta-analytic evidence indicates that MedDiet interventions reduce interleukin (IL)-6 and IL-1β, with a trend toward lower C-reactive protein. The Mediterranean diet also promotes beneficial shifts in gut microbiota composition, increasing short-chain fatty acid production and supporting epithelial barrier integrity, which contributes to its anti-inflammatory effects. Key Messages: Current evidence supports the Mediterranean diet as a primary cardiometabolic protective dietary approach with anti-inflammatory potential. Integrating precision and personalized nutrition strategies may help optimize its implementation, while straightforward, equity-focused approaches remain essential to translate biological potential into measurable population-level benefits. </p>.
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