ArticleAnnals of medicine2026
Impact of SARS-CoV-2 infection history on the clinical features and outcomes of patients with recurrent pulmonary tuberculosis: a retrospective case-control study.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
objectiveThe impact of prior SARS-CoV-2 infection on the clinical course of recurrent pulmonary tuberculosis (TB) remains poorly defined. This study aimed to compare clinical features, radiographic evolution, and outcomes in recurrent TB patients with and without a history of SARS-CoV-2 infection.
methodsA retrospective case-control study was conducted. Patients diagnosed with recurrent pulmonary TB between January 2019 and January 2025 were consecutively enrolled. A history of SARS-CoV-2 infection was defined by laboratory confirmation (RT-PCR or antigen test). The primary outcome was favorable treatment outcome (cure or treatment completion). The secondary outcome was time to radiographic lung recovery (≥50% lesion resolution). Propensity score matching (PSM), false discovery rate (FDR) correction for multiple comparisons, and multiple imputation by chained equations were applied.
resultsOf 355 patients with recurrent pulmonary TB, 139 had a history of SARS-CoV-2 infection. After PSM (105 matched pairs), the infection history group had a significantly higher proportion of patients undergoing invasive procedures (51.4% vs 36.2%) and a shorter median time to radiographic lung recovery (93 days vs 108 days). The difference in dyspnea (35.2% vs 25.7%) became non-significant after FDR correction (
conclusionA history of SARS-CoV-2 infection is associated with a greater need for invasive procedures and faster radiographic recovery, but is not independently associated with treatment outcomes. Enhanced monitoring is warranted, but established risk factors remain the primary prognostic determinants.
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