ArticleAnnals of medicine2026
A retrospective cohort study comparing the effects on inflammatory response and clinical outcomes of vancomycin-PMMA versus vancomycin-sulfate calcium in chronic osteomyelitis.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to compare the impact on inflammatory response, clinical efficacy, and safety between vancomycin-loaded polymethylmethacrylate (PMMA) and a combination of vancomycin-loaded PMMA with vancomycin sulfate calcium (PMMA-SC) in treating chronic osteomyelitis.
methodsA retrospective cohort study involved 244 patients with chronic osteomyelitis treated between January 2017 and December 2024. Patients were divided into PMMA (
resultsThe PMMA-SC group demonstrated significantly higher rates of infection control (87.29% vs. 72.22%,
conclusionThe combination of vancomycin sulfate calcium with PMMA was associated with improved outcomes compared to PMMA alone, potentially attributable to its association with enhanced control of infection and a more favorable modulation of the systemic inflammatory and immune response. These findings support its consideration as a promising therapeutic strategy for chronic osteomyelitis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.