ArticleAnnals of medicine2026
Thrombotic burden and longitudinal outcomes in Thai patients with polycythemia vera.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPolycythemia vera (PV) is a myeloproliferative neoplasm frequently complicated by thromboembolic events. However, data regarding thrombotic burden and long-term outcomes among Asian patients remain limited. MATERIALS AND
methodsWe conducted a retrospective cohort study at a tertiary referral center to evaluate thromboembolic events, treatment-related complications, disease progression, and overall survival in patients with PV.
resultsA total of 133 patients were included, with a median age of 61 years (range 18-88). Most patients were male (60.2%). Fifty-one patients (38.3%) experienced at least one thromboembolic event, with 54 events in total, of which 87% occurred before or at PV diagnosis. Arterial thrombosis accounted for 90.7% of all events. Age ≥60 years was significantly associated with thromboembolic events, with an odds ratio of 2.34 (95% confidence interval [CI], 1.07-5.11). After a median follow-up of 7.7 years, the 5-year overall survival was 82.7% (95% CI, 74.61-88.35). Prior thrombosis was associated with an increased risk of death (hazard ratio, 1.98; 95% CI, 1.15-3.42). Hydroxyurea resistance or intolerance occurred in 9.8% of patients. Bleeding complications were observed in 6.8%, including major bleeding in 4.5%. Fibrotic transformation, leukemic transformation, and secondary solid malignancies occurred in 4.5%, 3.8%, and 6.0% of patients, respectively.
conclusionThromboembolic events were common and predominantly arterial in this Asian PV cohort, occurring mainly before or at diagnosis. Prior thrombosis was associated with inferior survival. Long-term follow-up also revealed disease progression and secondary solid malignancies, underscoring the importance of continued surveillance.
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