Evidence map›Paper›PMID 42262834›Full record

ArticleAnnals of Indian Academy of Neurology2026

Sexual Health in Men and Women with Wilson's Disease: A Cross-Sectional Study.

Jalumuri Ss Anjusha, Doniparthi V Seshagiri, Lakshminarayanapuram G Viswanathan, Shaik Ahmed, Sinu Ezhumalai, Binu V Sreekumaran Nair, Madhu Nagappa, Sanjib Sinha

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Article in Annals of Indian Academy of Neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Jalumuri Ss AnjushaDepartment of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Doniparthi V SeshagiriDepartment of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Lakshminarayanapuram G ViswanathanDepartment of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Shaik AhmedDepartment of Biostatistics, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Sinu EzhumalaiDepartment of Psychiatric Social Work, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Binu V Sreekumaran NairDepartment of Biostatistics, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Madhu NagappaDepartment of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Sanjib SinhaDepartment of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesWilson's disease (WD) is a systemic copper toxicity disorder, manifesting as hepatic and neurological symptoms. Sexual health in WD is not well studied. This study aimed to understand sexual health impairment and its related factors in men and women with WD.

methodsMen with WD (MeWD) and women with WD (WoWD) were classified as being in the disease-active phase (DAP) or disease maintenance phase (DMP). Disease-related disability was assessed using the Global Assessment Scale for Wilson's Disease (GAS for WD). Sexual health was assessed with the Arizona Sexual Experience Scale (ASEX). Depression and anxiety were assessed using the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7) scales, respectively. Healthy men (MeH) and healthy women (WoH) underwent similar assessments for comparison.

resultsThe study included 48 MeWD (11 DAP, 37 DMP), 39 WoWD (12 DAP, 27 DMP), 29 MeH, and 34 WoH. In MeWD, ASEX scores (median [Q1-Q3]) were 13 (10-16) in DAP, 13 (11-14) in DMP, and 14 (12-16) in MeH, with no significant differences. However, in WoWD, ASEX scores were more impaired in DAP 19.5 (15.25-24.75) than in DMP 15 (14-17) ( P = 0.029) and WoH 14 (13-18) ( P = 0.025). ASEX scores correlated with GAS for WD in both MeWD ( P = 0.023) and WoWD ( P < 0.001), but not with 24-hour urinary copper excretion at diagnosis.

conclusionsMen and women with WD experience impaired sexual health, which may be related to disease-associated disability. Longitudinal disease registries are required to understand the role of copper metabolism in sexual health impairment in WD.

Indexed as

non-motor symptomssexual healthWilson’s disease

Identifiers

PMID42262834
PMCPMC13544868

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