ArticleMolecular biology reports2026
RT-qPCR-based transcriptional profiling of the effects of tarantula logoplex on inflammatory, oxidative stress and apoptosis pathways in remote organs in experimental lower extremity ischemia-reperfusion injury.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLower extremity ischemia and reperfusion (I/R) is a significant cellular damage event frequently encountered in clinical cases, causing local and systemic complications. This study investigated the protective and therapeutic efficacy of Tarantula logoplex
methodsThirty-five male albino rats were randomly divided into five groups: Control, I/R, TL, Pre-Ischemia (PI) + TL, and Pre-Reperfusion (PR) + TL. The I/R model consisted of 3 h of ischemia followed by 3 h of reperfusion. The process was monitored using a thermal camera.
resultsCompared to the control group, the I/R group had higher serum levels of liver Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP), Gamma-glutamyl Transferase (GGT), Total Protein (Tp), Total Bilrubin (T.bil) and Direct Bilrubin (D.Bil), heart (Troponin-I, Lactate Dehydrogenase and CK-MB) and kidney (Blood Urea Nitrogen, Creatinine, Phosphorus and Magnesium) function panels (p < 0.001), and lower albumin levels (p < 0.001). When compared to the TL, PI + TL, and PR + TL groups, the I/R group had lower levels of liver, heart, and kidney function panels and higher albumin levels (p < 0.001). Additionally, rt-PCR, TNF-α (Tumor Necrosis Factor-alpha), 8-OHdG (8-hydroxy-2'-deoxyguanosine), Hsp27 (Heat Shock Protein 27), collagen-1, and caspase-3 expression levels were found to be higher in the I/R group, partially decreased in the PI + TL groups, and significantly decreased in the PR + TL groups in heart, liver, and kidney tissues (p < 0.001).
conclusionThe TL application was found to have protective potential, showing a partial effect during ischemia and an even greater effect during reperfusion.
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