ArticleMolecular biology reports2026
Effects of Nicotine administration on α7nAChR, miR-124, STAT3, and inflammatory markers in Rat Lung Tissue.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundNicotine, the major alkaloid in tobacco, interacts with nicotinic acetylcholine receptors (nAChRs), particularly α7nAChR, which is involved in inflammatory regulation. MicroRNA‑124 (miR‑124) and signal transducer and activator of transcription 3 (STAT3) also participate in inflammatory signaling. This study investigated the effects of nicotine on α7nAChR, miR‑124, phosphorylated STAT3 (p‑STAT3), MCP‑1, and IL‑10 expression in rat lung tissue.
methodsAdult male Wistar rats (n = 8/group) received different doses of nicotine. Lung tissues were collected for molecular analyses. Expression of α7nAChR and miR‑124 was assessed using quantitative real‑time PCR (qRT‑PCR). Protein levels of α7nAChR and p‑STAT3 were evaluated by Western blotting, and MCP‑1 and IL‑10 levels were measured using ELISA.
resultsNicotine exposure was associated with a dose‑dependent increase in α7nAChR expression. miR‑124 expression increased at the lower nicotine dose but decreased at higher doses. Alterations in p‑STAT3 protein levels were also observed following nicotine administration. MCP‑1 levels decreased at the lower dose and increased at higher doses, whereas IL‑10 levels increased in nicotine‑treated groups.
conclusionNicotine administration was associated with changes in α7nAChR, miR‑124, p‑STAT3, MCP‑1, and IL‑10 expression in rat lung tissue, suggesting a potential association between nicotine exposure and inflammatory signaling pathways in the lung.
Indexed as
Identifiers
42262606What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.