Evidence map›Paper›PMID 42262592›Full record

ArticleSocial psychiatry and psychiatric epidemiology2026

Sex-specific drivers of non-affective psychotic disorders within migrant groups: A 25-year retrospective cohort study of 2 million migrants.

Jahin Ali Khan, Jordan Edwards, Britney Le, Daniel Lizotte, Kelly K Anderson

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Article in Social psychiatry and psychiatric epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Jahin Ali KhanDepartment of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, 1465 Richmond Street, London, ON, N6G 2M1, Canada. jkhan84@uwo.ca.
Jordan EdwardsOfford Centre for Child Studies, McMaster University, Hamilton, ON, Canada.
Britney LeICES Western, London, ON, Canada.
Daniel LizotteDepartment of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, 1465 Richmond Street, London, ON, N6G 2M1, Canada.
Kelly K AndersonDepartment of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, 1465 Richmond Street, London, ON, N6G 2M1, Canada.

Funding

CIHR Canada Graduate ScholarshipCouncil of Ontario Universities Ontario Women's Health Scholars Award
6 · The paper itself

Abstract

purposeMigration is a well-established risk factor for psychotic disorders; however, little is known about factors that may contribute to the risk of psychosis within migrant populations and whether these associations differ by sex. Thus, we sought to identify sex-specific factors that modify the risk of non-affective psychotic disorder (NAPD) among migrant groups.

methodsWe constructed a retrospective cohort of first-generation migrants who arrived in Ontario (Canada) between 1992-2011 (n = 1,964,884). Cohort members were followed in linked health administrative data to identify first-onset cases of NAPD using a validated algorithm. We stratified Poisson regression models by sex to estimate the effects of sociodemographic and migration-related factors on the risk of NAPD among men and women separately.

resultsThe incidence of NAPD was higher among migrant men than women (IRR = 1.20, 95% CI: 1.16, 1.23). African origin, family sponsorship, refugee status, and lack of proficiency in the official languages were associated with a higher risk of NAPD among both sexes, with a more pronounced effect in men. North African or Middle Eastern origin and younger age at migration showed specificity of effect for a higher risk of NAPD among men only. Among adult migrants (age 19 +), marital and common-law relationships exerted a greater protective effect among men, whereas higher education was protective among men only.

conclusionWe identified sex-based differences in factors that modify psychosis risk among migrant groups. These sex-specific factors may help explain variations in NAPD incidence and define high-risk subgroups for targeted prevention and early intervention efforts.

Indexed as

Psychotic DisordersTransients and MigrantsAdolescentAdultEmigrants and ImmigrantsFemaleHumansIncidenceMaleMiddle AgedOntarioRefugeesRetrospective StudiesRisk FactorsSex FactorsSocioeconomic FactorsHealth administrative dataMigrationPsychotic disordersSex differences

Identifiers

PMID42262592

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