Evidence map›Paper›PMID 42262538›Full record

ArticleNeuroradiology2026

Combined multiphase CTA and CTP in assessing cerebral collateral circulation and predicting prognosis in AIS/TIA with symptomatic MCA M1 stenosis/occlusion: a subacute, non-reperfused cohort.

Changgeng Fang, Xin Liu, Mengxing Wang, Weibin Gu, Wanying Duan, Ximing Nie, Zhe Zhang, Yuesong Pan, Liping Liu

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Changgeng FangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xin LiuDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Mengxing WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Weibin GuDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Wanying DuanDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Ximing NieDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zhe ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yuesong PanDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Liping LiuDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. lipingsister@gmail.com.

Funding

Chinese Stroke Association CSA, CSA2016KY001
6 · The paper itself

Abstract

purposeAccurate assessment of collateral circulation is essential for individualized treatment in ischemic cerebrovascular disease. This study aims to establish a comprehensive evaluation of cerebral collateral circulation and predict functional outcomes.

methodsThis multicenter prospective cohort study enrolled patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA) due to symptomatic intracranial atherosclerotic stenosis (sICAS), presenting within 7 days of symptom onset without acute thrombolysis or thrombectomy. All underwent multimodal CT imaging and had significant stenosis/occlusion of the middle cerebral artery (MCA) M1 segment. Collateral structure was evaluated via multiphase CTA (mCTA) score, and collateral function by average Tmax delay time between bilateral MCA territories. Patients were categorized into four groups: C (+) (good structure+function), C (-) (poor structure+function), C (mix1) (poor structure, good function), and C (mix2) (good structure, poor function). The primary outcome was modified Rankin Scale (mRS) score 0-2 at 90 days. A nomogram was constructed to predict this outcome, incorporating mCTA score, delay time, and other relevant clinical risk factors.

results471 patients were included: 191 in C (+) group, 45 in C (mix1) group, 128 in C (mix2) group, and 107 in C (-) group. Multivariate analysis revealed that C (+) group was significantly associated with mRS 0-2 at 90 days (adjusted odds ratio [aOR] 2.58, 95% CI 1.06-6.40; p = 0.04 vs. C [-]). The nomogram model showed good calibration and discrimination, with a C-statistic of 0.85 (95% CI 0.80-0.89).

conclusionA favorable comprehensive collateral profile is associated with better functional outcomes.

Indexed as

Cerebral AngiographyCollateral CirculationComputed Tomography AngiographyInfarction, Middle Cerebral ArteryIntracranial ArteriosclerosisIschemic Attack, TransientIschemic StrokeAgedCerebrovascular CirculationFemaleHumansMaleMiddle AgedMultimodal ImagingPredictive Value of TestsPrognosisComprehensive collateral circulationCT perfusionIschemic strokeMultimodal imagingMultiphase CTA

Identifiers

PMID42262538

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