Evidence map›Paper›PMID 42262507›Full record

ArticleEnvironmental science & technology2026

ToxBase: A Multidimensional ToxCast Reference Database for High-Throughput Human Exposome Analysis.

Ryan Nguyen, Griffin Rangel, Xingzhu Liu, Reuben A Santoso, Amogh Bantwal, Dylan H Ross, Ryan P Seguin, Jennifer Liem, Yvonne S Lin, Brian Pratt and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental science & technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ryan NguyenDepartment of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, United States.
Griffin RangelDepartment of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, United States.
Xingzhu LiuDepartment of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, United States.
Reuben A SantosoDepartment of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, United States.
Amogh BantwalDepartment of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, United States.
Dylan H RossDepartment of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, United States.ORCID 0009-0005-2943-2282
Ryan P SeguinDepartment of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, United States.
Jennifer LiemDepartment of Pharmaceutics, University of Washington, Seattle Washington 98195, United States.
Yvonne S LinDepartment of Pharmaceutics, University of Washington, Seattle Washington 98195, United States.
Brian PrattDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195, United States.
Brendan X MacLeanDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195, United States.
Michael J MacCossDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195, United States.ORCID 0000-0003-1853-0256
Libin XuDepartment of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, United States.ORCID 0000-0003-1021-5200

Funding

Large-Scale Characterization of ToxCast Compounds and Their Metabolites by High-Throughput Ion Mobility-Mass Spectrometry: Applications in Human Exposome StudiesF31ES037537 · NIEHS · UNIVERSITY OF WASHINGTON · PI Ryan Nguyen · 2025 to 2026
$90k
NIEHS NIH HHS F31 ES037537
6 · The paper itself

Abstract

High-resolution mass spectrometry (HRMS) is the gold-standard technique for comprehensively profiling chemical exposures in complex human matrices, making it a powerful analytical tool for advancing human exposome research. Yet the scarcity of HRMS reference data, including collision cross-section (CCS) measurements from ion mobility-mass spectrometry (IM-MS) and MS/MS fragmentation spectra, hinders confident structural annotation of chemical exposure agents across laboratories. We therefore developed ToxBase, a multidimensional (

Indexed as

Databases, FactualExposomeHumansLiquid Chromatography-Mass SpectrometryTandem Mass Spectrometrycollision cross sectionexposomeion mobility-mass spectrometryMS/MSsuspect screeningToxCast

Identifiers

PMID42262507
PMCPMC13296496

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.