Observational studyAnnals of African medicine2026
Efficacy of Intraoperative Intravenous Dexmedetomidine on Postoperative Analgesia among Patients following Gynecological Surgeries - A Comparative Observational Study.
Observational study in Annals of African medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
contextDexmedetomidine has been used as an adjuvant to minimize the adverse effects associated with opioids, either in the form of intravenous injection or intravenous infusion.
aimThe present study aimed to compare the efficacy of dexmedetomidine when administered via intravenous infusion and intravenous bolus injection. MATERIALS AND
methodsA comparative observational study was conducted among 1000 participants aged 35-65 years with American Society of Anesthesiologists physical status I/II, scheduled to undergo elective gynecological surgeries. Participants were divided into Group D (received a loading dose of bolus 0.5 µg/kg, followed by 0.3 µg/kg/h intravenous infusion of dexmedetomidine) and Group C (control group) 15 min before the induction of anesthesia. Hemodynamic variables, recovery time, rescue analgesia, pain scores, and any adverse events were recorded.
resultsParticipants in Group D had lower hemodynamic parameters (after 1 h till the end of surgery) ( P < 0.05). Participants in Group D took fewer rescue analgesics compared to Group C ( P = 0.001), and recovery time was prolonged in Group D ( P = 0.001). Pain scores were lower in Group D compared to Group C ( P = 0.001).
conclusionA loading dose of intravenous bolus followed by intravenous infusion of dexmedetomidine is a valuable adjunct in the perioperative management of such patients, offering potential benefits in enhancing recovery and reducing the need for postsurgical analgesia.
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