ArticleACS infectious diseases2026
Synthesis of 4-Aminoindole-Containing Cephalosporin Prodrugs and Their Biological Activity against
Sangmi Oh, Helena I M Boshoff, Jose Santinni O Roma, Aidan Boving, Danielle M Weiner, April Walker, Laura E Via, Clifton E Barry
Abstract read
In one paragraphArticle in ACS infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Sangmi OhTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland 20892, United States.ORCID 0000-0003-0895-1110 Helena I M BoshoffTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland 20892, United States.ORCID 0000-0002-4333-206X Jose Santinni O RomaTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland 20892, United States.
Aidan BovingTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland 20892, United States.
Danielle M WeinerTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland 20892, United States.
April WalkerTuberculosis Imaging Program, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland 20892, United States.
Laura E ViaTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland 20892, United States.ORCID 0000-0001-6074-9521 Clifton E BarryTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland 20892, United States.ORCID 0000-0002-2927-270X Funding
PATHOGENIC MECHANISMS OF MYCOBACTERIUM TUBERCULOSISZ01AI000693 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI BARRY, CLIFTON · 1993 to 2008
$8.1MBill & Melinda Gates Foundation INV-001727Intramural NIH HHS Z01 AI000693
6 · The paper itselfAbstract
Indole 4-carboxamides are promising prodrugs that liberate 4-aminoindole, which poisons tryptophan biosynthesis in
Indexed as
Antitubercular AgentsCephalosporinsIndolesMycobacterium tuberculosisProdrugsMicrobial Sensitivity TestsTryptophanAntitubercular AgentsCephalosporinsIndolesProdrugsTryptophan4-aminoindoleantitubercular activitycephalosporinsprodrugstryptophan biosynthesistuberculosis
Identifiers
PMID42262488
PMCPMC13366586
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