Evidence map›Paper›PMID 42262317›Full record

ReviewACS chemical biology2026

Engineering Protein Stability with Small Molecules: A Review of the ecDHFR Destabilizing Domain System.

Miriam Ruhinda, Roenick P Olmo, Bianca C Burini

Abstract readReview
In one paragraph

Review in ACS chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Miriam RuhindaFlorida Medical Entomology Laboratory, University of Florida - IFAS, Vero Beach, Florida32962, United States.ORCID 0009-0000-1893-1506
Roenick P OlmoCNRS UPR9022, Inserm U1257, Université de Strasbourg , Strasbourg67084, France.
Bianca C BuriniFlorida Medical Entomology Laboratory, University of Florida - IFAS, Vero Beach, Florida32962, United States.ORCID 0000-0002-2986-2435

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The

Indexed as

Protein EngineeringTetrahydrofolate DehydrogenaseAnimalsEscherichia coliHumansProtein DomainsProtein Processing, Post-TranslationalProtein StabilityTetrahydrofolate Dehydrogenase

Identifiers

PMID42262317
PMCPMC13288455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.