ArticlemBio2026
The McbR transcription factor links the intracellular folate pool to virulence in enterohemorrhagic
Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Bacterial pathogens coordinate the expression of metabolically expensive virulence programs during host colonization. While the impact of environmental cues on virulence has been extensively studied, direct sensing of metabolic intermediates to inform virulence expression is less understood. Competition with the resident microbiota in the case of an infection has a massive impact on the bacteria's central metabolism, which can be used as a cue for the timely expression of virulence factors. Here, we identify how fluctuations in the intracellular folate pool can affect the expression of virulence factors in the enteric pathogen enterohemorrhagic IMPORTANCE: Host colonization requires enteric pathogens to tightly regulate their virulence program in response to a multitude of factors. In this work, we show that the bacterial physiological state directly informs pathogenic behavior in enterohemorrhagic
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