Evidence map›Paper›PMID 42262097›Full record

ArticlemBio2026

A cysteine-rich domain of the

Corinna Probst, Chloe Insler, Catherine A Denning-Jannace, Estefany Y Reyes, Jonathan L Messerschmidt, Lukas M du Plooy, Charles Giamberardino, Connie B Nichols, Yohannes Asfaw, Mari L Shinohara and 2 more

Abstract read
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Corinna ProbstDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-1154-5116
Chloe InslerDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Catherine A Denning-JannaceDepartment of Chemistry and Biochemistry, University of North Carolina, Greensboro, North Carolina, USA.
Estefany Y ReyesDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, USA.
Jonathan L MesserschmidtDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, USA.
Lukas M du PlooyUniversity of Exeter, MRC Centre for Medical Mycology, Exeter, England, United Kingdom.
Charles GiamberardinoDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0001-7813-5616
Connie B NicholsDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Yohannes AsfawDivision of Laboratory Animal Resources, Duke University, Durham, North Carolina, USA.
Mari L ShinoharaDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-6808-9844
Katherine J FranzDepartment of Chemistry, Duke University, Durham, North Carolina, USA.
J Andrew AlspaughDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-3009-627X

Funding

Intracellular Osteopontin induces Pathologic Macrophage phenotypes in Pulmonary FibrosisF30HL175889 · NHLBI · DUKE UNIVERSITY · PI Jonathan Leigh Messerschmidt · 2024 to 2026
$164k
Duke University Bridge Funding 4532750National Institute of Allergy and Infectious Diseases AI184401NHLBI NIH HHS F30 HL175889NIGMS NIH HHS GM041840NIGMS NIH HHS GM145035Tri-Institutional Molecular Mycology and Pathogenesis Trainings Program T32-Al052080
6 · The paper itself

Abstract

The ability to sense, import, and detoxify copper (Cu) has been shown to be crucial for microbial pathogens to survive within an infected host. Previous studies conducted with the opportunistic human fungal pathogen IMPORTANCE: Copper is an essential micronutrient required for survival in all kingdoms of life, as it is used as a catalytic cofactor for many essential processes in the cell. In turn, this reactivity of copper ions makes elevated levels of free copper toxic to the cell. This dual nature of copper-essential for life but toxic at elevated levels-is used by our innate immune system in a process called nutritional immunity to combat and kill invading pathogens. In this work, we explore how the fungal human pathogen

Indexed as

CopperCryptococcus neoformansFungal ProteinsStress, PhysiologicalTranscription FactorsAnimalsCryptococcosisCysteineDisease Models, AnimalGene Expression Regulation, FungalMiceProtein DomainsVirulenceCopperCysteineFungal ProteinsTranscription Factorsfungal pathogenesismetal homeostasisnutritional immunity

Identifiers

PMID42262097
PMCPMC13343922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.