Evidence map›Paper›PMID 42262093›Full record

ArticleMicrobiology spectrum2026

CYP51C Y319H and H349R substitutions cannot confer azole resistance in

Ya Bin Zhou, Alexey A Grum-Grzhimaylo, Martin Meijer, Bart Kraak, Jos Houbraken

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ya Bin ZhouDepartment of Dermatology, Peking University Third Hospital, Beijing, China.ORCID 0000-0001-5775-3861
Alexey A Grum-GrzhimayloWesterdijk Fungal Biodiversity Institute, Utrecht, the Netherlands.
Martin MeijerWesterdijk Fungal Biodiversity Institute, Utrecht, the Netherlands.
Bart KraakWesterdijk Fungal Biodiversity Institute, Utrecht, the Netherlands.
Jos HoubrakenWesterdijk Fungal Biodiversity Institute, Utrecht, the Netherlands.ORCID 0000-0003-4893-4438

Funding

HORIZON EUROPE Marie Sklodowska-Curie Actions 101145976
6 · The paper itself

Abstract

Azole antifungals inhibit the cytochrome P450-dependent lanosterol 14-α-demethylase (CYP51), an essential enzyme in the ergosterol biosynthetic pathway. While azole resistance mechanisms are well established in

Indexed as

Antifungal AgentsAspergillus flavusAzolesDrug Resistance, FungalFungal ProteinsSterol 14-DemethylaseAmino Acid SubstitutionCytochrome P-450 Enzyme SystemMicrobial Sensitivity TestsMutationAntifungal AgentsAzolesCytochrome P-450 Enzyme SystemFungal ProteinsSterol 14-DemethylaseAspergillus flavusazole resistanceCYP51Cfitness costsite-directed mutagenesis

Identifiers

PMID42262093
PMCPMC13339886

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.