Evidence map›Paper›PMID 42262081›Full record

ArticlemBio2026

Pathways of copper import and utilization that support respiration in

Grayson Barnes, Lars Hederstedt, Oriana S Fisher, Claes von Wachenfeldt, John D Helmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Grayson BarnesDepartment of Microbiology, Cornell University, Ithaca, New York, USA.ORCID 0009-0000-9411-599X
Lars HederstedtThe Microbiology Group, Department of Biology, Lund University, Lund, Sweden.ORCID 0000-0002-6650-6296
Oriana S FisherDepartment of Molecular Biology and Biochemistry, Wesleyan University, Middletown, Connecticut, USA.ORCID 0000-0003-3215-0831
Claes von WachenfeldtThe Microbiology Group, Department of Biology, Lund University, Lund, Sweden.ORCID 0000-0001-8950-3218
John D HelmannDepartment of Microbiology, Cornell University, Ithaca, New York, USA.ORCID 0000-0002-3832-3249

Funding

Bacillus subtilis Stress ResponsesR35GM122461 · NIGMS · CORNELL UNIVERSITY · PI John D Helmann · 2017 to 2026
$7.6M
Structural and functional basis of bacterial transcriptional regulationR35GM150644 · NIGMS · WESLEYAN UNIVERSITY · PI Oriana S Fisher · 2023 to 2026
$1.6M
NIGMS NIH HHS R35 GM122461NIGMS NIH HHS R35 GM150644
6 · The paper itself

Abstract

Copper is an enzyme cofactor that is essential for cellular respiration in most aerobic organisms but can be toxic in excess. Although most copper enzymes are localized within or external to the cell membrane, proper copper loading often relies on copper import into the cytosol. In IMPORTANCE: Copper is a critical micronutrient for bacteria; however, it is toxic in excess. This leads to the cell having tightly regulated import and export systems to prevent intoxication while having sufficient copper for cellular needs. Copper export has been well studied, but copper import and the effects of copper starvation are less defined. In this article, we characterize the

Indexed as

Bacillus subtilisCopperBacterial ProteinsBiological TransportElectron Transport Complex IVMembrane ProteinsMembrane Transport ProteinsBacterial ProteinsCopperElectron Transport Complex IVMembrane ProteinsMembrane Transport ProteinsBacillus subtiliscoppermetal resistancemulticopper oxidasesrespirationtransporters

Identifiers

PMID42262081
PMCPMC13344008

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.