Evidence map›Paper›PMID 42262076›Full record

ArticlemBio2026

High-throughput profiling of the IgG and IgA response to the

Lorenzo Giacani, Linda H Xu, Amit Oberai, Jozelyn V Pablo, Christopher Hung, Andy A Teng, Adam D Shandling, Kelika A Konda, Silver K Vargas, Michael Reyes Diaz and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lorenzo GiacaniDepartment of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-3889-7274
Linda H XuDepartment of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.
Amit OberaiAntigen Discovery, Inc., Irvine, California, USA.
Jozelyn V PabloAntigen Discovery, Inc., Irvine, California, USA.
Christopher HungAntigen Discovery, Inc., Irvine, California, USA.
Andy A TengAntigen Discovery, Inc., Irvine, California, USA.
Adam D ShandlingAntigen Discovery, Inc., Irvine, California, USA.
Kelika A KondaCenter for Interdisciplinary Studies in Sexuality, AIDS and Society, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado, Lima, Peru.
Silver K VargasCenter for Interdisciplinary Studies in Sexuality, AIDS and Society, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado, Lima, Peru.
Michael Reyes DiazCenter for Interdisciplinary Studies in Sexuality, AIDS and Society, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado, Lima, Peru.
Carlos F CaceresCenter for Interdisciplinary Studies in Sexuality, AIDS and Society, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado, Lima, Peru.
Jeffrey D KlausnerDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Joseph J CampoAntigen Discovery, Inc., Irvine, California, USA.

Funding

Syphilis Immunology and Biology to Improve Clinical Management and Vaccine DesignR01AI139265 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Jeffrey David Klausner · 2018 to 2026
$4.8M
Discovery of Treponema pallidum antigens for development of a sensitive and specific diagnostic test for syphilisR43AI149804 · NIAID · IMMPORT THERAPEUTICS, INC. · PI CAMPO, JOSEPH J. · 2020 to 2021
$600k
NIAID NIH HHS R01 AI139265NIAID NIH HHS R43 AI149804
6 · The paper itself

Abstract

Syphilis continues to be a significant global health concern. To define the extent of the IgG and IgA antibody reactome in patients with syphilis and identify reactive antigens and reactivity patterns that could facilitate early diagnosis and possibly serve as biomarkers for treatment response and staging, we developed a pan-proteomic microarray carrying 98.8% (1,009 antigens) of the annotated polypeptides of two

Indexed as

Antibodies, BacterialImmunoglobulin AImmunoglobulin GProteomeSyphilisTreponemaTreponema pallidumAdultAntigens, BacterialBacterial ProteinsFemaleHigh-Throughput Screening AssaysHumansMaleMiddle AgedProtein Array AnalysisAntibodies, BacterialAntigens, BacterialBacterial ProteinsImmunoglobulin AImmunoglobulin GProteomeprotein arrayserodiagnosisstagingsyphilistreatment responseTreponema pallidum

Identifiers

PMID42262076
PMCPMC13343974

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.