ArticleBipolar disorders2026
Bipolar Disorder Psychosis Risk Predicts Cue Discrimination on the AX-Continuous Performance Task Paradigm.
Article in Bipolar disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
objectivesBipolar Disorder (BD)-characterized by mania, affective lability, and elevated psychosis risk-is associated with sustained attention deficits. However, evidence regarding performance on the AX-Continuous Performance test task (AX-CPT), a task reliably impaired in schizophrenia-spectrum psychosis, is mixed. This study examined whether individual differences in mania/affective lability risk and psychosis risk, across cohorts of BD and BD-at-risk individuals, were associated with altered AX-CPT performance.
methodsThe standard measures d'context and A-cue bias quantified AX-CPT performance. Factors from the Mood Spectrum Self Report (MOODS-SR-L) indexed lifetime mania/affective lability risk (psychomotor activation, suicidality, and mixed instability) and lifetime psychosis risk. Linear regressions were performed for dimensional continuous aims (Aims 1-2) for both d'context and A-cue bias. Tests between BD with low and high-risk groups (Aims 3-4) were completed with ANCOVAs for both AX-CPT output measures.
resultsIn the final sample of euthymic BD (n = 27) and at-risk individuals (n = 121), higher levels of psychosis and mania/affective lability risk were associated with reduced target discrimination (d'context; absolute t's > 2.015, p's < 0.047), but not with altered A-cue bias. Group comparisons showed no significant differences for either AX-CPT measure. Associations with d'context from Aims 1-2 remained after covarying for current depressive symptoms but were removed when covarying for current mania severity (absolute t's < 1.26, all p's > 0.203).
conclusionsTarget discrimination deficits were associated dimensionally with psychosis and mania/affective lability risk but not categorically with BD diagnosis. This suggests scope for dimensional risk models for understanding sustained attention deficits in BD and at-risk individuals and highlights contributions of mania/affective lability and psychosis risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.